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CANDY   MEDICATION 


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MEDICATION 


BY 

BERNARD  FANTUS,  M.  D. 


i  Professor  of  Pharmacology  and  Therapeutics,  College ifof 

2  Medicine,  University  of  Illinois,   Chicago. 

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ST.  LOUIS 

C.  V.  MOSBY  COMPANY 

1915 


Via  ^.-4 


Copyright    1915,  by  C.  V.  Mosby  Company 


"R:r5GO 


Press  of 

C.  V.  Mosby  Company 

Si.  Louis 


PREFACE. 

CANDY  MEDICATION  has  given  such  delight- 
ful results  in  practice  among  children  that  the 
author  believes  it  should  be  more  widely  known 
and  used.  A  formulary  to  serve  as  the  common 
meeting  ground  for  the  prescribing  physician  and 
the  dispensing  pharmacist  seems  absolutely  neces- 
sary to  make  this  form  of  medication  more  gener- 
ally available;  and  it  is  mainly  to  supply  this  for- 
mulary that  this  little  book  has  been  published. 

Researches  conducted  by  the  author  in  the  Phar- 
macologic Laboratory  of  the  University  of  Illinois 
during  the  past  five  years,  as  well  as  the  experience 
gained  by  the  use  of  this  form  of  medication  in 
private  practice,  form  the  basis  of  this  publication. 

To  give  the  best  results,  the  sweet  tablets  de- 
scribed in  this  formulary  should  be  freshly  prepared 
on  physician's  order;  thereby  securing  efficiency 
and  palatability  to  the  highest  degree,  and  enabling 
the  physician  to  prescribe  the  dose  and  combina- 
tion needed  for  the  particular  case  in  hand.  To 
bring  these  tablets  into  the  category  of  extempor- 
aneous preparations,  the  author  has  elaborated  the 
process  of  "fat  covering"  which  makes  the  prepara- 
tion of  these  tablets  no  more  difficult  than  the  mak- 
ing of  pills  or  of  suppositories. 

In  the  pages  that  precede  the  formulary,  an  at- 
tempt has  been  made  to  present  the  principles 
that   have    been    used    in    the    elaboration    of    the 


8  PREFACE 

formulae,  so  that  formulae  for  other  medicaments 
suitable  to  this  form  of  administration  may  be 
developed. 

Concise  directions  on  the  care  and  use  of  the  tab- 
let machine  have  been  included,  to  enable  any  phar- 
macist equipped  with  an  inexpensive  tablet  machine 
to  prepare  these  tablets  without  difficulty. 

The  author  is  keenly  aware  of  the  fact  that  there 
are  probably  still  some  imperfections  in  the  for- 
mulae given  herein;  though  he  has  spared  neither 
time  nor  labor  in  making  them  as  perfect  as  possible. 
Therefore,  comments  and  criticisms,  as  well  as 
suggestions,  are  most  welcome,  and  will  receive 
careful  consideration. 

It  is  the  author's  hope  that  this  booklet  may  be 
instrumental  in  robbing  childhood  of  one  of  its 
terrors,  namely,  nasty  medicine;  that  it  may  lessen 
the  difficulties  experienced  by  nurse  and  mother 
in  giving  medicament  to  the  sick  child;  and  help 
to  make  the  doctor  more  popular  with  the  little  ones. 

BERNARD  FANTUS,   M.D. 

Chicago,  March,  1915. 


CONTENTS. 


Chapter  Page 

I.     Historical  Introduction — .  11 

II.     Tabellae  Dulces .-... - 14 

III.  The  Uses  of  Sweet  Tablets 16 

IV.  The  Making  of  Sweet  Tablets 23 

V.     The  Tablet  Machine - - 27 

VI.     The    Construction   of    Formulae    for   Sweet 

Tablets -- 31 

Choice  of  Flavor - - 31 

Subduing  of  Tastes .— 31 

Choice  of  Color 34 

VII.     Formulae  for  the  Preparation  of  Sweet  Tablets  35 

VIII.     Formulae  for  Stock  Preparations 72 

References — - - -  '5 

Index - - — - - '  ' 


CANDY  MEDICATION 

CHAPTER  I. 
HISTORICAL  INTRODUCTION. 

THE  IDEA  of  presenting  medicine  in  candy 
form  is  really  very  old.  The  term  confection, 
which  originally  meant  a  medicinal  compound 
being  derived  from  the  the  Latin  word  ''conficere,'' 
to  put  together,  has  been  applied  since  the  days  of 
classical  antiquity  to  mixtures  of  medicinal  sub- 
stances with  saccharine  matter.  The  only  official 
relics  of  this  once  very  extensive  class  of  prepara- 
tions are  the  confection  of  rose  and  the  confection 
of  senna;  both  of  which,  however,  are  also  practi- 
cally obsolete.  The  reason  for  this  is  not  difficult 
to  find.  Neither  of  them  come  up  to  our  modern 
ideas  of  a  confection.  We  may  officially  call  them 
a  confection,  but  a  youngster  would  be  disrespectful 
enough  to  disagree  with  the  pharmacopoeia. 

More  closely  akin  to  candy  are  lozenges,  and  yet 
they  are  not  real  candy.  The  only  one  among  them 
that  is  pleasant  is  the  santonin  lozenge;  and  it  is 
the  only  one  that  is  popular.  An  especially  good 
imitation  of  candy  form  are  the  deservedly  popular 
so-called  German  worm  lozenges.  It  was  acquaint- 
ance with  these  that  led  the  writer  to  seek  for  other 
real  candy  medicaments.  He  could  find  only  two 
such  upon  the  market:  viz.,  Calomel  Tablets  under 
the  name  of  "Aromatic  Calomel,"  and  Phenol- 
phthalein    Tablets    under    various    fanciful    trade- 


12  CANDY   MEDICATION 

names,  such  as  "Purgen,"  Phenolax,"  etc.,  unless 
"Candy  Cathartic  Cascarets,"  and  the  French 
candy  laxative  known  as  "Tamar  Indien"  were 
also  to  be  included. 

Convinced  that  administration  in  candy  form 
would  be  ideal  for  children,  the  author  took  a 
number  of  years  ago  a  course  of  instruction  with  a 
candy-maker,  in  the  hope  of  finding  in  the  con- 
fectioner's art  some  new  form  of  pleasant  adminis- 
tration for  medicine.  He  made  sulphur  taffy  and 
cod-liver  oil  chocolate  creams;^  but  these  and  a 
large  number  of  other  attempts  were  unsuccessful. 
It  may  be  of  interest,  in  this  connection,  to  note 
that,  in  1911,  Sir  James  Sawyer^  published  in  "The 
Lancet"  a  process  for  the  production  of  what  he 
calls  "cremulae"  or  medicated  chocolate  creams. 
They  were  prepared  by  evaporating  a  mixture  of 
sugar  and  of  milk  to  the  consistency  of  paste,  in 
which  various  medicaments  might  be  incorporated, 
and  which  is  then  covered  with  chocolate,  as  in  the 
popular  chocolate  drop.  This  is,  as  will  be  seen, 
a  troublesome  process.  The  author's  studies  in 
the  candy  shop  seemed  to  point  to  "fondant"  as 
the  most  suitable  candy  form  for  purposes  of  medi- 
cation. "Fondant",  however,  has  the  disadvantage 
of  becoming  hard  with  age.  Free  from  this  objec- 
tion and  closely  similar  to  the  "fondant"  is  a 
rather  lightly  compressed  tablet  made  of  finely 
powdered  cane  sugar.  And  so  finally  the  tablet 
form  was  chosen  as  the  best  and  most  convenient 
for  candy  medication — a  form  which  was  already 


HISTORICAL   INTRODUCTION  13 

in  successful  use,  as  has  been  stated,  for  the  ad- 
ministration of  calomel  and  of  phenolphthalein. 
For  such  tablets  the  term  tabellae  dulces,^  or  sweet 
tablets,  might  be  proposed. 


CHAPTER  II. 
TABELLAE  DULCES. 

TO  BE  SUCCESSFUL,  sweet  tablets  must  meet 
the  following  requirements: 

1.  They  must  be  perfectly  delicious  sweets,  at- 
tractive in  form,  color,  and  odor;  and  free  from  the 
slightest  suspicion  of  disagreeable  or  medicinal  taste. 

2.  They  must  disintegrate  rapidly  in  the  mouth; 
for  a  sick  child  will  usually  not  suck  candy  as  a 
healthy  youngster  would. 

3.  To  constitute  a  real  advance  in  therapeutics, 
it  must  be  possible  for  the  average  pharmacist 
to  prepare  them  extemporaneously,  so  that  the 
physician  may  be  able  to  fit  the  medicament  to 
suit  the  case,  and  that  the  pharmacist  may  not  be 
forced  to  carry  in  stock  a  large  assortment  of  these 
more  or  less  perishable  goods. 

In  view  of  these  exacting  requirements,  it  may 
seem  remarkable  that  over  fifty  different  medica- 
ments are  at  present  available  for  administration 
in  the  form  of  sweet  tablets.  This  has  been  accom- 
plished by  taking  advantage  of  the  fact  that  some 
medicines  are  practically  tasteless;  that  modern 
synthetic  chemistry  has  enriched  our  resources  in 
this  direction  by  the  production  of  a  large  number 
of  tasteless,  or  almost  tasteless,  and  yet  active 
substances;  and  that  many  of  the  isolated  active 
principles  of  drugs  are  easily  disguised.  In  some 
cases  a  chemical  trick  is  successful,  e.  g.,  using  a 
little  alkali  or  a  little  acid  to  render  the  substance 


TABELLAE   DULCES.  IS 

less  soluble  in  the  mouth.  Some  of  the  bitterest 
alkaloids,  e.g.,  sti^ychnine,  have  been  rendered 
available  for  candy  medication  by  the  use  of  finely 
powdered  fuller's  earth,  or  of  Lloyd's  Reagent,  to 
be  described  later.  Quite  a  number  of  almost  in- 
soluble substances  of  slight  but  lingering  taste  can 
be  made  perfectly  pleasant  by  saccharinization. 


CHAPTER  III. 
THE  USES  OF  SWEET  TABLETS. 

IT  MAY  seem  strange  that  modern  pharmacy 
which  boasts  of  so  many  elegant  and  palatable 
preparations  suitable  for  adults,  has  thus  far  done 
so  little  to  render  medicine  more  acceptable  to 
children;  and  yet  attractiveness  and  palatability 
are  even  more  important  for  the  little  ones  than 
for  the  grown-ups.  Syrups  have  hitherto  been  our 
chief  aids  in  making  medicines  more  pleasant  for 
children.  Unfortunately,  however,  many  a  child 
has  had  its  palate  offended  by  liquid  medicines  to 
such  a  degree  that  it  abhors  spoon-medicine  of 
any  kind,  and  will  struggle  even  against  the  most 
palatable.  When  one  witnesses  the  struggling  of 
the  average  child  against  the  average  medicine,  one 
cannot  but  wonder  whether  at  times  the  struggle 
does  not  do  more  harm  than  the  medicine  can  do 
good,  and  wish  that  we  had  other  means  of  adminis- 
tering medicines  to  the  little  ones.  As  all  children 
love  candy,  this  would  seem  the  form  most  desirable 
for  them.  For  one  who  has  not  used  candy  medi- 
cation there  is  a  revelation  in  store  in  the  positive 
enjoyment  and  eagerness  with  which  children  take 
these  sweet  tablets.  And  many  a  petted  child 
that  has  grown  up  into  a  sensitive  woman,  who  be- 
lieves she  cannot  swallow  a  pill,  also  cannot  and 
will  not  take  medicine.  It  so  happens  that  just 
these  are  often  excessively  fond  of  candy  and. will 
take  candy  medicine.     Another  use  for  candy  medi- 


THE  USES  OF  SWEET  TABLETS.  17 

cation  is  in  the  treatment  of  the  insane,  who  fre- 
quently will  not  take  medicine,  but  may  take  it 
in  candy  form. 

It  may  be  of  interest  to  see  how  many  indica- 
tions may  be  met,  confining  oneself  entirely  to  the 
list  of  candy  medicaments: 

1.   For  effect  upon  the  alimentary  tract: 

Absorbent: 
Charcoal. 

Antacid: 
Chalk. 
Magnesia. 
Sodium  Bicarbonate. 

Emetics : 

Apomorphine. 

Tartar  Emetic. 

Emetine.  . 

Antiemetics: 
Cocaine. 
Anaesthesine. 
Morphine. 

Bismuth  Subnitrate  or  subcarbonate. 
Chalk. 
Cerium  Oxalate. 

Antidiarrheal: 

Bismuth  Subnitrate  or  Subcarbonate. 

Tannalbin. 

Morphine. 

Chalk. 


18  CANDY  MEDICATION. 

Cathartics  : 
Calomel. 

Mercury  with  Chalk. 
Phenolphthalein. 
Elaterin. 

Resin  of  Podophyllum. 
Resin  of  Jalap. 
Senna. 
Sulphur. 

Antispasmodic: 
Atropine. 

Intestinal  A  ntiseptic : 
Magnesium  salicylate. 
Mercurials. 
Lactic  acid  ferment. 

Anthelmintic : 
Santonin. 

2.  For  effect  upon  the  respiratory  system: 

Expectorants : 
Apomorphine. 
Emetine. 
Terpin  hydrate. 
Sajodin. 

Antitussic: 
Heroine. 
Morphine. 
Sabromin. 

A  ntispasmodic : 
Atropine. 


THE  USES  OF  SWEET  TABLETS.  19 

3.  For  effect  upon  the  circulatory  system: 

Circulatory  Stimulants: 

Digitalis. 

Strophanthin. 

Atropine. 

Strychnine. 

Caffeine. 
Circulatory  Depressant: 

Aconitine. 
Vaso-Dilator : 

Nitroglycerin. 

4.  For  effect  upon  genito-urinary  system: 

Diuretic : 

Diuretin. 

Caffeine. 
Urinary  Antiseptic : 

Hexamethylenamine. 

5.  For  effect  upon  skin: 

Diaphoretic: 

Pilocarpine. 

Dover's  Powder. 
A  nhydrotic : 

Atropine. 

6.  For  effect  upon  nervous  system: 

Depressants: 
Morphine. 
Hyoscine. 
Sabromin. 
Sulphonmethane. 
Adalin. 


20  ANDY  MEDICATION. 

Stimulants : 
Atropine. 
Cocaine. 
Strychnine. 
Caffeine. 

7.  Antipyretics: 

Acetphenetidin. 

Antipyrin. 

Acetylamidosalol  (Salophen). 

Aconitine. 

Aristochin. 

8.  Hematinics: 

Iron, 

Reduced  Iron, 

Iron  carbonate,  saccharated. 
Arsenic. 

9.  Tonics:  , 

Iron,  quinine,  strychnine. 
10.  Specifics: 

In  Malaria: 

Aristochin. 

Saloquinine. 

Arsenic. 
In  Syphilis: 

Mercurials. 

Sajodin. 
In  Rheumatic  Fever: 

Acetylsalicylic  acid  (Aspirin). 

Acetylamidosalol  (Salophen). 

Magnesium  salicylate. 
In  Myxedema: 

Thyroid. 


THE  USES    OF  SWEET   TABLETS  21 

Of  course,  a  large  variety  of  combinations  of 
these  could  be  elaborated. 

It,  therefore,  seems  established  that  we  have,  in 
candy  medication,  a  method  of  fairly  extensive 
applicability;  an  almost  complete  therapeutic  ar- 
mamentarium of  the  greatest  possible  value  in  the 
treatment  of  children.  For  the  tiny  infant  this 
method  is,  of  course,  unsuitable  as  well  as  unneces- 
sary. As  soon,  however,  as  the  youngster  com- 
mences to  know  what  candy  is,  it  is  ready  for 
candy  medication.  It  is  particularly  during  the 
ages  of  from  three  to  ten  that  this  form  of  admin- 
istration is  indicated. 

Several  objections  have  been  raised  against  this 
method.  Perhaps  the  most  serious  one  lies  in  the 
danger  of  poisoning,  from  the  fact  that  children 
enjoy  these  tablets  so  much  that  they  are  likely 
to  eat  a  large  number  of  them  at  one  time,  should 
the  mother  be  careless  enough  to  leave  them  within 
reach.  The  only  way  to  prevent  such  an  occur- 
rence is  not  to  prescribe  more  tablets  than  would 
constitute  a  safe  dose  should  all  of  them  be  taken 
at  one  time.  It  is  better  to  have  the  patient  get 
a  new  supply  daily  than  to  have  a  single  case  of 
death  or  serious  disturbance  occur  from  this  source. 

Another  objection  that  has  been  raised  is  that 
the  dose  of  some  of  the  medicines  is  very  small. 
In  the  case  of  such  remedies  as  sulphur  and  chalk 
the  author  admits  that  the  dose  is  perhaps  too 
small  to  be  of  practical  importance.  In  the  case 
of  most  other  medicaments,  however,  the  smallness 


22  CANDY  MEDICATION 

of  dose  is  of  advantage  rather  than  of  disadvan- 
tage, in  that  it  necessitates  administration  at  short 
intervals.  If  the  administration  of  small  doses  fre- 
quently repeated  until  the  desired  effect  is  obtained 
is  a  good  principle  in  practice,  it  is  particularly  so 
in  pediatrics.  For  are  not  all  the  vital  processes 
of  the  child  much  more  rapid  than  those  of  the 
adult;  are  not  its  bowel  movements,  its  urinations 
more  frequent,  does  it  not  need  nourishment  more 
often?     Then  why  not  medicine? 


Chapter  iv. 
the  making  of  sweet  tablets. 

IT  IS  GENERALLY  supposed  that  tablet  mak- 
ing is  an  art,  requiring  special  expertness  and 
expensive  machinery.  Now  while  both  of  these 
ideas  are  correct  when  the  preparation  of  a  large 
variety  of  tablets  and  of  large  quantities  is  con- 
templated, they  are  erroneous  in  regard  to  the 
making  of  prescription  quantities  of  these  sweet 
tablets,  which  present  a  comparatively  simple  and 
relatively  uniform  problem  in  tablet  making. 

Though  the  process  of  making  moulded  tablets 
was  introduced  by  Dr.  Robert  M.  Fuller  of  New 
York  before  the  Academy  of  Medicine  on  February 
21,  1878,  in  a  paper  entitled:  "Dose-Dispensing 
Simplified,"^  the  simplification  was  evidently  not 
such  that  druggists  could  notice  it;  for  moulded 
tablets  have  not  become  popular  among  them, 
perhaps  mainly  because  they  require  drying. 
Likewise  are  compressed  tablets,  which  were  intro- 
duced even  earlier  by  Professor  Brockeden  of  Eng- 
land in  1844,  considered  unsuitable  for  extempor- 
aneous preparation,  as  granulation  of  the  powder 
by  moistening  is  believed  to  be  necessary;  and 
this,  of  course,  also  requires  drying. 

A  step  in  the  direction  of  rendering  tablet  making 
available  for  extemporaneous  preparation  was  made 
in  1909  by  A.  Schleimer^  by  advocating  the  use  of 
cacao  butter  in  lieu  of  granulation  of  the  powder 
and  subsequent  drying.     This  brings  tablets  into 


24  CANDY   MEDICATION 

the  category  of  extemporaneous  preparations.  All 
that  is  necessary  is  to  add  three  percent  of  cacao 
butter  to  the  powder,  and  it  is  ready  for  immediate 
compression  in  a  tablet  machine.  Having  found 
that  cacao  butter  is  liable  to  become  rancid  on 
keeping  of  some  tablets  made  with  it,  the  author 
experimented  to  find  a  substitute  devoid  of  this 
tendency,  and  found  it  in  paraffin  of  low  melting 
point. ^  For  tablets  that  are  not  to  be  kept  for  any 
length  of  time,  cacao  butter  is  preferable,  as  it 
melts  readily  and  is  digestible.  The  amount  of 
paraffin,  however,  that  enters  into  the  composition 
of  each  tablet  is  so  small  that  in  spite  of  its  indi- 
gestibility,  it  seems  that  it  could  not  meet  with 
any  but  theoretic  objection.  Either  of  these 
materials,  in  form  of  fine  shavings,  is  added  to  the 
extent  of  three  to  five  per  cent,  with  just  sufficient 
trituration  to  distribute  fairly  well.  Excessive 
trituration  lessens  the  efficiency  of  the  lubricating 
agent.  If  the  tablet  has  a  tendency  to  stick  to  the 
punches,  the  material  can  be  worked  better  if  a 
little  talcum,  say  three  per  cent,  is  added  to  the 
powder  by  stirring  it  in  with  a  spatula  rather  than 
by  trituration.  This  process  renders  tablet  making 
no  more  difficult  or  time-consuming  than  the 
making  of  pills  or  capsules. 

The  author  has  succeeded  in  still  further  simpli- 
fying the  process  by  the  preparation  of  what  he 
would  propose  to  call  "fat  sugar."  Having  noticed 
that  the  addition  of,  say,  10  per  cent,  of  powdered 
cacao  to  sugar  forms   an   almost  ideal  powder  for 


THE   MAKING  OF  SWEET  TABLETS.  25 

immediate  compression  in  the  tablet  machine,  the 
idea  occurred  to  him  to  reproduce,  as  nearly  as 
possible,  the  physical  condition  of  cacao  by  covering 
each  particle  of  powdered  starch  with  a  thin  layer 
of  fat,  which  can  readily  be  done  by  triturating 
starch  with  liquid  petrolatum.  While  other  fat, 
such  as  cacao  butter,  "Crisco"  or  paraffin,  might 
be  used  for  this  purpose,  by  dissolving  the  fat  in 
ether  and  thus  distributing  it  over  the  starch,  per- 
mitting the  ether  subsequently  to  evaporate,  the 
author  has  found  that  liquid  petrolatum,  1  part, 
distributed  over  3  parts  of  starch  forms  a  powder 
which  added  to  sugar  in  proportion  of  about  twenty 
per  cent,  renders  it  admirably  suitable  for  com- 
pression in  a  tablet  machine.  The  starch  might 
be  sweetened  by  previously  triturating  it  with  an 
alcoholic  solution  of  saccharin  and  permitting  the 
alcohol  to  evaporate ;  though  this  sweetening  is  not 
essential.  For  starch,  thus  prepared,  the  author 
proposes  the  name  "fat  starch",  the  formula  for 
which  will  be  found  in  Chapter  VIII.  Sugars  con- 
taining twenty  per  cent,  of  "fat  starch",  are  ready 
for  immediate  compression  in  the  tablet  machine; 
and  admit  of  admixture  of  a  moderate  amount  of 
medicament  without  losing  this  quality.  If  a  large 
amount  of  medicament  is  to  be  incorporated,  then 
an  additional  amount  of  "fat  starch"  should  be 
allowed.  Sugars  containing  "fat  starch"  the 
author  has  called  "fat  sugars"  for  want  of  a  better 
name.  He  is  aware  of  the  fact  that  petrolatum  is 
not  a  fat  in  the  true  sense  of  the  word.     Never- 


26  CANDY   MEDICATION. 

theless  it  is,  no  doubt,  its  "fatty"  nature  that  does 
the  work;  other  fatty  substances,  such  as  cacao 
butter  or  "Crisco",  producing  the  same  result  as 
far  as  rendering  the  powder  suitable  for  compres- 
sion in  the  tablet  machine  is  concerned.  Liquid 
petrolatum  has  the  advantage  over  these  of  being 
devoid  of  tendency  to  rancidity. 

Excessive  trituration  interferes  with  the  effi- 
ciency of  the  fat  starch,  evidently  by  distributing 
the  fat  all  over  the  powder,  rendering  it  homo- 
geneous, which  is  inimical  to  tablet  making. 
Therefore  in  case  of  the  red  fat  sugar  which  is  used 
as  a  vehicle  for  poisonous  medicaments  that  re- 
quire very  thorough  trituration,  it  is  recommended 
that  the  fat  starch  be  added  after  the  trituration. 

The  author  would  suggest  that  the  pharmacist 
prepare  the  various  fat  sugars  described  in  Chapter 
Vm  and  that  he  keep  them  on  hand,  in  a  cool  and 
dark  place,  adding  the  medicament  as  prescribed 
by  the  physician,  making  use  of  Chapter  VII  for 
guidance  in  the  elaboration  of  individual  formulae. 


CHAPTER  V. 
THE  TABLET  MACHINE. 

THE  GROUXDLESSXESS  of  the  second  ob- 
jection to  tablet  making  by  retail  druggists, 
namely,  the  necessity  of  possessing  expensive 
machinery,  can  perhaps  best  be  shown  by  the 
illustrations  here  given.  The  simplest  and  yet 
practical  form  of  tablet  machine  known  to  the 
author  is  the  "Xo.  25"  machine  of  Whitall-Tatum 
Company  of  Philadelphia  ^Fig.  1) .  The  price  of 
this  machine  is  about  ten  dollars. 

Its  chief  disadvantage  is  that  it  works  rather 
slowly,  as  the  powder  must  be  put  into  the  die 
by  hand  with  a  small  tool  furnished  with  the 
machine.  An  automatically  feeding  machine  of 
reasonable  price  is  the  "Eureka"  Hand  Tablet 
Machine,  furnished  by  the  F.  J.  Stokes  Co.,  of 
Philadelphia  (^Fig.  2).  This  machine  may  also  be 
obtained  for  motor  power. 

Detailed  directions  for  the  putting  up  and  the 
use  of  these  machines  seem  unnecessary  here  as 
they  accompany  the  machine  when  sent  out  by  the 
manufacturer.  A  few  points  on  the  care  of  the 
tablet  machine  may,  however,  be  brought  out  in 
order  to  save  the  novice  trouble  and  mishaps. 

All  compressing  machines  for  tablet  making  con- 
sist essentially  of  a  die  and  two  punches,  an  upper 
and  a  lower.  It  is  important  that  these  be  kept 
scrupulously  clean  and  free  from  rust,  nicks  and 
scratches;  for  unless  these  parts  be  perfectly  smooth 


28 


CANDY   MEDICATION. 


it  is  impossible  to  get  them  to  work  properly.  When 
not  in  use,  they  should  be  kept  completely  covered 
with  vaselin  or  else  immersed  in  liquid  petrolatum, 
in  order  to  protect  them  against  rust.     When  re- 


Fig.  1 

A  simple  yet  practical  form  of  tablet  machine. 


quired  for  use,  the  grease  is  removed  from  them  as 
completely  as  possible  by  means  of  a  soft  cloth. 

In  putting  the  die  and  punches  into  the  machine, 
it  is  best  to  put  in  the  lower  punch  first,  making 
sure  that  it  has  been  pushed  completely  down  into 


THE  TABLET   MACHINE. 


29 


its  socket.  Then  put  In  the  die,  so  that  the  top 
of  the  die  be  exactly  flush  all  around  with  the  table 
of  the  machine.  See  to  it  that  the  face  of  the  lower 
punch  be  exactly  flush  with  the  top  of  the  die  when 
the  punch  is  at  its  highest  point.  Then  insert  the 
upper  punch  in  its  socket;  and  let  it  enter  the  die 
before  locking  it  in  place,  so  as  to  insure  perfect 
alignment. 


The  Eureka  Hand  Tablet  Machine.     An  automatically  feeding 
machine  of  reasonable  price. 

When  die  and  punches  are  to  be  removed,  take 
out  the  upper  punch  first,  then  the  lower  punch 
and  die,  which  may  come  out  suddenly  and  be  in- 
jured by  knocking  against  the  upper  punch  if  the 
latter  be  still  in  place. 

When  particles  of  the  powder  stick  to  the  die 
or  punches,  they  should  not  be  scraped  off  with  a 
hard  instrument,  as  this  is  liable  to  scratch,  but 


30  CANDY  MEDICATION. 

should  be  wiped  off  with  a  soft,  slightly  moistened 
cloth.  To  prevent  sticking,  a  little  talcum  may  be 
used,  sprinkled  over  the  powder  and  lightly  mixed 
by  stirring  with  a  spatula. 

When  the  upper  face  of  the  tablet  splits  off,  we 
speak  of  ''capping."  To  overcome  this,  ten  per 
cent,  of  fat  starch  may  be  added  to  the  powder. 
Should  "capping"  still  occur,  the  amount  of  fat 
starch  might  be  increased.  "Capping"  may  also 
be  due  to  the  use  of  excessive  pressure.  It  may  fur- 
thermore be  due  to  die  or  punches  being  worn  or 
damaged.  When  this  has  occurred,  the  best  thing 
to  do  is  to  get  a  new  set  of  punches,  or  to  have  the 
damaged  one  refinished  by  an  expert  mechanic, 
preferably  the  makers  of  the  tablet  machine. 

It  would  lead  us  beyond  the  scope  of  this  work 
to  give  detailed  directions  for  making  'ablets  of 
all  kinds.  A  pharmacist  who  has  equipped  himself 
with  a  tablet  machine  and  has  developed  the  am- 
bition to  make  a  general  line  of  tablets'^  may  be  re- 
ferred to  Mr.  Joseph  R.  Wood's  book^  on  this 
subject. 


CHAPTER  VI. 

THE  CONSTRUCTION  OF  FORMULAE  FOR 
SWEET  TABLETS. 

Choice  of  Flavor. 

THERE  are  quite  a  number  of  medicines  suf- 
ficiently free  from  taste  and  odor  to  be  made 
perfectly  pleasant  by  the  mere  admixture  of  sugar 
and  of  flavoring.  These  can,  of  course,  be  pre- 
pared with  any  flavor  desired.  In  the  formulary, 
rose  has  been  chosen  as  the  flavor  under  these  cir- 
cumstances, but  any  other  flavor  may  be  used 
instead. 

Substances  that  have  a  slightly  acrid  taste  are 
generally  best  disguised  by  peppermint.  For 
sour  taste,  lemon  is  best.  Wintergreen  was  chosen 
as  the  flavor  for  salicylates. 

Substances  that  have  a  slightly  bitter  taste  are 
best  disguised  by  "vanilla  cacao  sugar."  For 
drugs  that,  in  addition  to  a  slightly  bitter  taste, 
have  an  odor  that  needs  disguising,  "cinnamon 
cacao  sugar"  is  to  be  preferred. 

The  Subduing  of  Tastes. 

There  are  quite  a  number  of  drugs  that  have  a 
tendency  to  leave  a  rather  persistent  disagreeable 
after-taste,  drugs  of  slight  solubility,  particles  of 
which  remain  on  the  tongue  longer  than  the  sugar 
does,  so  that  their  taste  lingers  after  the  taste  of 
the  sugar  has  disappeared.     For  such  drugs  sac- 


32  CANDY   MEDICATION. 

charinization  solves  the  problem  of  candy  medica- 
tion.    The  saccharin  will  be  most  efficient,  as  the 
author  has  shown  by  repeated  experiments,  if  it 
is  directly  incorporated  with  the  drug  in  solution 
rather    than    in    dry    form.     Saccharinization   is, 
therefore,  carried  out  in  the  formulary  by  triturat- 
ing the  drug  with  a  saturated  (3  per  cent.)  alcoholic 
solution  of  saccharin,   and  permitting  the  alcohol 
to   evaporate   subsequently.     The   drying   may  be 
expedited  by  using  a  hot  mortar.     When  alcohol 
is   not  permissible,   as    in   the   case   of   "Alcresta" 
preparations  (see  below),  dry  saccharinization  must 
be  used  instead,  that  is,  triturating  the  drug  with 
saccharin,  preferably  a  1  to  10  trituration.     Like- 
wise when  time  does  not  permit   moist  saccharin- 
ization, triturating  the  substance  with  a  somewhat 
larger  amount  of  saccharin  will  answer  the  purpose. 
A  second  expedient  for  the  subduing  of  taste  is 
fat  covering,  which  consists  of  triturating  the  drug 
with  liquid  petrolatum  or  other  fat,  e.  g.,  Crisco  in 
ether,  and  permitting  the  ether  to  evaporate.     The 
thin  film  of  fat  left  on  the  drug  delays  its  solution 
to  a  slight  degree,   yet  sufficiently  to  reduce  the 
taste,  so  that  certain  drugs — such  as  aspirin,  digi- 
talis,  diuretin — can   be   administered   in   the   form 
of   sweet  tablets  in   useful   dose.     In   these   cases, 
saccharinization   and   fat   covering   combined   give 
the  best  results. 

Most  of  the  alkaloids  can  be  administered  in 
candy  form  by  saccharinization  with  or  without 
additional  fat  covering,  and,  in  the  case  of  some,  the 


CONSTRUCTION  OF  FORMULAE  FOR  SWEET  TABLETS    33 

addition  of  sodium  bicarbonate  is  still  further  use- 
ful in  lessening  the  solubility,  thereby  subduing  the 
taste.  Only  in  the  case  of  the  bitterest  alkaloids 
such  as  strychnine  and  of  alkaloids  that  have  to 
be  given  in  large  doses  such  as  quinine  are  different 
expedients  necessary.  For  quinine,  aristochin  or 
saloquinine  solve  the  problem.  For  strychnine, 
Lloyd's  "Alcresta"  strychnine  gives  good  results. 
In  1910,  John  Uri  Lloyd^  of  Cincinnati  discovered 
that  the  addition  of  fuller's  earth  to  alkaloids  al- 
most completely  abolished  their  bitter  taste.  He 
found  on  further  research  that  this  activity  resided 
in  the  finest  particles,  especially  those  of  colloidal 
dimensions,  which  could  be  separated  from  the 
coarser  portion  of  fuller's  earth  by  elutriation. 
By  means  of  this  powder,  now  known  as  Lloyd's 
Reagent,  it  is  possible  to  obtain  the  bitterest  alka- 
loids, even  strychnine,  in  almost  tasteless  form. 
That  this  strychnine  combination  is  still  active,  can 
be  proved  by  the  fact  that  it  will  kill  a  dog  almost 
as  readily  as  the  uncombined  strychnine.  Lloyd 
has  coined  the  name  ''Alcresta"  for  these  alkaloidal 
combinations;  they  are  marketed  by  Ely  Lilly  and 
Company.  The  combination  of  the  strychnine 
with  fuller's  earth  is  destroyed  by  alkali  and  by 
alcohol.  Hence  alcohol  must  not  be  added  to  the 
powder  after  the  Alcresta  combination  has  been 
incorporated.  The  addition  of  a  little  acid  lessens 
the  bitterness  of  the  combination  by  lessening  solu- 
bility in  the  mouth.  The  addition  of  acid  is  also 
of  advantage  to  lessen  the  solubility  in  the  saliva. 


34  CANDY  MEDICATION. 

and  with  it  the  taste,  of  such  resinous  bodies  as  the 
resin  of  podophyllum. 

Choice  of  Color. 

To  indicate  tablets  containing  poisonous  sub- 
stances, a  dark  red  color  is  chosen,  unless  cacao 
disguises  the  taste  better.  It  would  be  advisable 
not  to  prescribe  more  than  a  small  number  of  such 
tablets  to  be  dispensed  at  one  time,  so  as  to  pre- 
vent the  possibility  of  poisoning.  The  choice  of 
the  other  colors  has  been  more  or  less  without 
special  principle  underlying  it,  yellow  having  been 
chosen  for  lemon,  and  green  for  wintergreen,  leav- 
ing pink  for  rose  and  white  for  peppermint.  The 
relation  of  color  to  flavor  can,  of  course,  be  varied. 


CHAPTER  VII. 

FORMULAE    FOR   THE    PREPARATION    OF 
SWEET  TABLETS 

The  subjoined  formulae  are  published  to  serve 
for  guidance  in  the  preparation  of  sweet  tablets 
and  as  a  basis  for  further  study  and  improvement. 

The  doses  given  are  children's  doses,  none  of 
them  exceeding  a  dose  safe  for  a  child  three  years 
of  age.  Most  of  the  tablets  carry  as  large  a  dose 
as  can  well  be  given  in  this  way;  which  in  some 
cases,  though  not  in  many,  is  not  sufficient  for  a 
three-year-old  child.  Where  a  larger  dose  can 
easily  be  disguised  in  the  same  manner,  this  fact 
is  noted  in  connection  with  the  formulae. 

A  warning  may  not  be  amiss,  in  this  connection, 
not  to  put  up  in  this  form  anything  that  does  not 
result  in  a  faultlessly  pleasant,  actually  delicious 
candy.  For  confidence  once  lost  is  not  easily  re- 
stored. 

h^Formulae  for  the  preparation  of  the  stock  sugars 
referred  to  in  this  formulary  will  be  found  in  Chap- 
ter VIII.  They  can  all  be  prepared  extemporane- 
ously. The  drying  necessary  after  the  addition  of 
coloring  may  be  expedited  by  the  use  of  a  warm 
mortar.  Nevertheless,  alternate  formulae  have 
been  inserted  in  most  instances  to  facilitate  rapid 
extemporaneous  compounding,  in  case  the  stock 
sugar  be  not  at  hand. 

While  most  of  these  tablets  keep  well,  a  few 
deteriorate.    In  any  case,  the  freshly  prepared  tablet 


36  CANDY  MEDICATION. 

will  be  found  more  pleasant  than  one  that  has 
become  stale  by  being  kept  in  stock. 

Should  difficulty  be  experienced  in  the  compres- 
sion of  some  of  these  tablets,  the  addition  of  a 
little  shaved  paraffin  by  gentle  trituration  in  a 
mortar ;  or  the  stirring  in  of  a  little  talcum  powder 
with  a  spatula;  or  both  measures  combined  will 
probably  overcome  the  trouble.  Some  powders 
work  best  with  light  pressure;  others  require 
rather  heavy  pressure. 

1.  TABELLAE  ACETPHENETIDINI  DULCES. 
Sweet  Tablets  of  Acetphenetidin. 

0.06  Gm.  (gr.  1). 

Caution: — Only  a  moderate  number  should  be  ordered  at 
one  time. 

Acetphenetidin 6.00  Gm. 

Alcoholic  solution  of  saccharin,  3%.    2,00  Cc. 
Vanilla  cacao  sugar 24.00  Gm. 

Mix    the    acetphenetidin    with    the    alcoholic    solution    of 

saccharin  (in  a  hot  mortar  if  in  a  hurry)  and  permit  the 
alcohol  to  evaporate;  then  mix  with  the  vanilla  cacao  sugar 
by  thorough  trituration  in  a  mortar;  and  compress  in  a  tablet 
machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Acetphenetidin 6.00  Gm. 

Saccharin 0.06  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 21.00  Gm. 

Mix  the  saccharin  with  the  tincture  of  vanilla,  then  add 
the  acetphenetidin  and  permit  the  alcohol  to  evaporate. 
Finally  add  the  other  ingredients,  triturating  until  they  are 
thoroughly  mixed.  Compress  in  a  tablet  machine,  using 
3/8-inch  die  and  punches,  to  make  one  hundred  0.30  Gm. 
tablets. 


FORMULARY  37 

2.  TABELLAE  ACETYLAMIDOSALOLI   DULCES. 
Sweet  Tablets  of  Acetylamidosalol  (Salophen). 

0.06  Gm.  (gr.  1). 

Acetylamidosalol 6.00  Gm. 

Green  fat  sugar 24.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar,  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to 
make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Acetylamidosalol 6.00  Gm. 

Spirit  of  gaultheria. 1.00  Cc. 

Malachite  green  solution,  1:1000....    1.00  Cc. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 18.00  Gm. 

Mix  the  acetylamidosalol  and  the  sugar  with  the  coloring 
and  the  flavor  by  thorough  trituration;  add  the  fat  starch 
by  gentle  trituration;  and  compress  in  a  tablet  machine, 
using  3/8-inch  die  and  punches,  to  make  one  hundred  0.3 
Gm.  tablets. 

3.  TABELLAE  ACIDI  ACETYLSALICYLICI   DULCES. 
Sweet    Tablets    of    Acetylsalicylic    Acid    (Aspirin). 

0.015  Gm.  (gr.  1/4.) 

Acetylsalicylic  acid 1.50  Gm. 

Alcoholic  solution  of  saccharin,  3%.    1.50  Cc. 

Liquid  petrolatum 0.50  Cc. 

Yellow  fat  sugar 28.00  Gm. 

Mix  the  acetylsalicylic  acid  with  the  alcoholic  solution  of 
saccharin  (in  a  hot  mortar  if  in  a  hurry),  and  permit  the  alco- 
hol to  evaporate.  Add  the  liquid  petrolatum  and  triturate. 
Finally  mix  with  the  yellow  fat  sugar  and  compress  in  a 
tablet  machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 

4.  TABELLAE  ACONITINI  DULCES. 

Sweet  Tablets  of  Aconitine. 

0.00003  Gm.  (gr.  1/2000). 
Caution: — Order  only  a  small  number  at  one  time. 

Aconitine,  crystallized 0.003  Gm. 

Red  fat  sugar 30.00  Gm. 


38  CANDY   MEDICATION. 

Mix  the  aconitine  with  the  red  fat  sugar  by  very  thorough 
trituration  in  a  mortar  and  compress  in  a  tablet  machine, 
using  3/8-inch  die  and  punches,  to  make  one  hundred  0.30 
Gm.  tablets. 

Alternate  Formula. 

Aconitine,  crystallized 0.003  Gm. 

Carmine 0.75  Gm. 

Spirit  of  cinnamon,  10% 0.30  Cc. 

Fat  starch 6. 00  Gm. 

Sugar,  powdered 23.25  Gm. 

Triturate  the  aconitine  with  the  sugar,  added  in  portions, 
until  well  mixed.  Add  the  spirit  of  cinnamon  and  the  car- 
mine and  triturate  again  until  the  red  color  is  perfectly  uni- 
form. Then  add  the  fat  starch,  triturating  gently  and  for  a 
short  time  only.  Compress  in  tablet  machine,  using  3/8-inch 
die  and  punches,  and  make  one  hundred  0.30  Gm.  tablets. 

5.  TABELLAE  ADALINI   DULCES. 
Sweet  Tablets  of  Adalin. 

0.03  Gm.  (gr.  1/2). 

Caution: — Only    a    moderate    number   should    be    ordered 

at  one  time. 

Adalin 3.00  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    4.00  Gm. 
White  sugar  fat 27.00  Gm. 

Mix  the  alcoholic  solution  of  saccharin  with  the  adalin 
(in  a  hot  mortar  if  in  a  hurry),  and  permit  the  alcohol  to 
evaporate.  Then  mix  thoroughly  with  the  white  fat  sugar 
and  compress  in  a  tablet  machine,  using  3/8-inch  die  and 
punches,  to  make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Adalin.. 3.00  Gm. 

Saccharin 0. 12  Gm. 

Spirit  of  peppermint 0.50  Cc. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 21.00  Gm. 

Mix  the  saccharin  with  the  spirit  of  peppermint,  then  add 

the  adalin,  and  triturate.  Then  incorporate  the  sugar  by 
thorough  trituration.  Finally  add  the  fat  starch  and  tritu- 
rate gently.  Compress  in  tablet  machine,  using  3/8-inch 
die  and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 


FORMULARY  39 

6.  TABELLAE  ANAESTHESINI   DULCES. 

Sweet  Tablets  of  Anaesthesine. 

0.015  Gm.  (gr.  1/4;. 

Not  more  than  a  small  number  of  these  tablets  should  be 
ordered  at  one  time. 

Anaesthesine 1.50  Gm. 

Pink  fat  sugar 28.50  Gm. 

Mix  the  anaesthesine  with  the  pink  fat  sugar  and  com- 
press in  tablet  machine,  using  3/8-inch  die  and  punches,  to 
make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Anaesthesine 1.50  Gm. 

Spirit  of  rose,  1% 0.60  Cc. 

Carmine 0.20  Gm, 

Fat    starch 6.00  Gm. 

Sugar,  powdered 22.50  Gm. 

Triturate  the  anaesthesine  with  the  sugar  and  the  spirit  of 
rose,  add  the  carmine,  and  tricurate  until  thoroughly  mixed. 
Finally,  add  the  fat  starch  with  gentle  trituration  and  com- 
press in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to 
make  one  hundred  0.30  Gm.  tablets. 

7.  TABELLAE  AXTIMOXII  ET  POTASSII 

TARTRATIS  DULCES. 

Sweet  Tablets  of   Antimony  and   Potassium   Tartrate 
(Tartar  Emetic). 

0,0006  Gm.  (gr.  1/100). 
Caution: — Only  a  moderate  number  of  these  tablets  should 
be_ ordered  at  one  time,  0.030  Gm.  having  produced  death  in 
children.  It  would  take  fifty  of  these  tablets,  however,  to 
yield  such  dose.  Larger  dose  might  be  administered  in  this 
form. 

Antimony  and  potassium  tartrate.  .  .    0.06  Gm. 

Red  fat  sugar 18.00  Gm. 

^lix  by  thorough  trituration  in  a  mortar  and  compress  in 
tablet  machine,  using  5,  16-inch  die  and  punches,  to  make 
one  hundred  0.18  Gm.  tablets. 

Alternate  Formula. 

Antimony  and  potassium  tartrate.  .  .    0.06  Gm. 

Carmine 0.50  Gm. 

Spirit  of  cinnamon,  10% 0.20  Cc. 

Fat  starch 3.60  Gm. 

Sugar,  powdered 14.40  Gm. 


40  CANDY  MEDICATION. 

Having  thoroughly  triturated  the  antimony  and  potassium 
tartrate  with  the  sugar,  add  the  coloring  and  the  flavoring; 
and  triturate  again  until  the  color  is  perfectly  uniform.  Then 
add  the  fat  starch,  triturating  gently  and  for  a  short  time 
only.  Compress  in  a  tablet  machine  using  5/16-inch  die  and 
punches,  to  make  one  hundred  0.18  Gm.  tablets. 

8.  TABELLAE  ANTIPYRINAE  DULCES. 
Sweet  Tablets  of  Antipyrine. 

0.015     Gm.  (gr.  1/4). 

Caution: — Only  a  moderate  number  should  be  ordered 
at  one  time. 

Antipyrine 1.50  Gm. 

Alcoholic  solution  of  saccharin,  3%.  .    3.00  Cc. 

Liquid  petrolatum 0.50  Cc. 

Vanilla  cacao  sugar 28.00  Gm, 

Mix  the  antipyrine  with  the  alcoholic  solution  of  sac- 
charin (in  a  hot  mortar  if  in  a  hurry)  and  permit  the  alcohol 
to  evaporate.  Add  the  liquid  petrolatum  and  triturate. 
Then  incorporate  the  vanilla  cacao  sugar;  and  compress  in  a 
tablet  machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Antipyrine 1.50  Gm. 

Saccharin 0.09  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Liquid  petrolatum 0.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 25. 00  Gm. 

Mix  the  tincture  of  vanilla  with  the  saccharin,  add  the 
antipyrine  and  permit  the  alcohol  to  evaporate.  Add  the 
liquid  petrolatum  and  triturate.  Then  incorporate  the  cacao 
powder  and  the  sugar  by  thorough  trituration;  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

9.  TABELLAE  APOMORPHINAE  DULCES. 
Sweet  Tablets  of  Apomorphine. 

0.0006  Gm.  (gr.  1/100). 

Caution: — Only  a  small  number  should  be  ordered  at  one 
time;  two  milligrams  of  Sipomorphine  having  produced 
alarming  collapse  in  a  child. 


FORMULARY.  41 

Apomorphine  hydrochloride 0,06  Gm. 

Vanilla  cacao  su^ar 30.00  Gm. 

Mix  the  ingredients  by  thorough  trituration  in  a  mortar; 
and  compress  in  a  tablet  machine,  using  3/8-inch  die  and 
punches,  to  make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Apomorphine  hydrochloride 0.06  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 27.00  Gm. 

Directions,  same  as  above. 

10.  TABELLAE  ARISTOCHINAE  DULCES. 
Sweet  Tablets  of  Aristochin. 

0.06  Gm.  (gr.  1). 

Aristochin 6.00  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    3.00  Cc. 

Sodium  bicarbonate 1.00  Gm. 

Vanilla  cacao  sugar 23.00  Gm. 

Mix  the  aristochin  with  the  alcoholic  solution  of  saccharin 
(in  a  hot  mortar  if  in  a  hurry)  and  permit  the  alcohol  to 
evaporate.  Then  add  the  vanilla  cacao  sugar,  and  finally 
the  sodium  bicarbonate  by  thorough  trituration  in  a  mortar. 
Compress  in  a  tablet  machine,  using  3/8-inch  die  and  punches 
to  make  one  hundred  0.30  Gm.  tablets. 

Note: — If  any  difficulty  be  experienced  in  compressing 
this  powder  into  tablets,  the  addition  of  a  little  shaved 
paraffin  will  probably  overcome  the  trouble. 

Alternate  Formula. 

Aristochin 6.00  Gm. 

Saccharin 0.09  Gm. 

Sodium  bicarbonate 1.00  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 20.00  Gm. 

Mix  the  saccharin  with  the  tincture  of  vanilla,  add  the 
aristochin  and  mix  by  trituration.  Incorporate  the  cacao 
powder,  the  sugar,  and  finally  the  sodium  bicarbonate. 
Mix  by  thorough  trituration  in  a  mortar  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Note: — See  above  note. 


42  CANDY  MEDICATION. 

11.  TABELLAE  ARSENI  TRIOXIDI   DULCES. 
Sweet  Tablets  of  Arsenic  Trioxide. 

0.0006  Gm.  (gr.  1/100). 

Caution: — Owing  to  the  toxicity  of  arsenic  trioxide   not 
more  than  a  small  number  should  be  ordered  at  one  time. 
Larger  doses  could  be  administered  in  this  form. 

Arsenic  trioxide 0.06  Gm. 

Red  fat  sugar 18.00  Gm. 

Mix  the  arsenic  trioxide  with  the  red  fat  sugar  by  thorough 
trituration  in  a  mortar  and  compress  in  a  tablet  machine, 
using  5/16-inch  die  and  punches,  to  make  one  hundred  0.18 
Gm.  tablets. 

Alternate  Formula. 

Arsenic  trioxide 0.06  Gm. 

Carmine 0.50  Gm. 

Spirit  of  cinnamon,  10% 0.20  Cc. 

Fat  starch 3.60  Gm. 

Sugar,  powdered 14.40  Gm. 

Having  triturated  the  arsenic  trioxide  with  the  sugar,  add 
the  carmine  and  the  spirit  of  cinnamon,  and  triturate  again 
until  the  color  is  perfectly  uniform.  Then  add  the  fat 
starch,  triturating  gently  and  for  a  short  time  only.  Com- 
press in  a  tablet  machine,  using  5/16-inch  die  and  punches, 
to  make  one  hundred  0.18  Gm.  tablets. 


12.  TABELLAE  ATROPINAE  DULCES. 
Sweet  Tablets  of  Atropine. 

0.0003  Gm.  (gr.  1/200). 

Caution: — Only  a  small  number  should  be  ordered  at  one 
time. 

Atropine  sulphate 0.03  Gm. 

Vanilla  cacao  sugar 30.00  Gm. 

Mix  the  atropine  sulphate  with  the  vanilla  cacao  sugar 
by  thorough  trituration  in  a  mortar;  then  compress  in  a  tab- 
let machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 


FORMULARY.  43 

Alternate  Formula. 

Atropine  sulphate 0.03  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 27,00  Gm. 

Triturate  the  atropine  sulphate  with  the  sugar  until 
thoroughly  mixed;  then  add  the  cacao  powder  and  the  tinc- 
ture of  vanilla,  and  triturate  again  until  the  color  is  per- 
fectly uniform.  Compress  in  tablet  machine,  using  3/8-inch 
die  and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 

13.  TABELLAE  BISMUTHI  SUBCARBONATIS 
DULCES. 

Sweet  Tablets  of  Bismuth  Subcarbonate. 

0.20  Gm.  (gr.  3)  . 

Bismuth  subcarbonate 20.00  Gm. 

Fat  starch 2.00  Gm. 

Pink  fat  sugar 18.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.40  Gm.   tablets. 

Alternate  Formula. 

Bismuth  subcarbonate 20.00  Gm. 

Carmine 0.20  Gm. 

Spirit  of  rose,  1  % 0.40  Cc. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 14.00  Gm. 

Thoroughly  mix  the  bismuth  subcarbonate  with  the  sugar, 
the  carmine,  and  the  spirit  of  rose  by  trituration  in  a  mortar; 
add  the  fat  starch  by  gentle  trituration;  and  compress  in  a 
tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.40  Gm.  tablets. 

14.  TABELLAE  BISMUTHI  SUBNITRATIS 
DULCES. 

Sweet  Tablets  of  Bismuth  Subnitrate. 

0.20  Gm.  (gr.  3). 

Bismuth  subnitrate 20.00  Gm. 

Fat  starch 2.00  Gm. 

Pink  fat  sugar 18.00  Gm. 


44  CANDY  MEDICATION. 

Mix  by  thorough  trituration  in  a  mortar  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.40  Gm.  tablets. 

Alternate  Formula. 

Bismuth  subnitrate 20.00  Gm. 

Carmine 0.20  Gm. 

Spirit  of  rose,  1% 0.40  Cc. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 14.00  Gm. 

Thoroughly  mix  the  bismuth  subnitrate  with  the  sugar, 
the  carmine,  and  the  spirit  of  rose  by  trituration  in  a  mortar; 
add  the  fat  starch  by  gentle  trituration;  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.40  Gm.  tablets. 


15.  TABELLAE  CAFFEINAE  DULCES. 
Sweet  Tablets  of  Caffeine. 

0.006  Gm.  (gr.  1/10). 

Caffeine  (alkaloid) 0.60  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    4.00  Cc. 
Vanilla  cacao  sugar 29.30  Gm. 

Mix  the  alcoholic  solution  of  saccharin  with  the  caffeine 
(in  a|hot  mortar  if  in  a  hurry)  and  permit  the  alcohol  to 
evaporate.  Then  mix  with  the  vanilla  cacao  sugar  and  com- 
press in  a  tablet  machine,  using  3/8-inch  die  and  punches, 
to  make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Caffeine  (alkaloid) 0.60  Gm. 

Saccharin 0. 12  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 26.30  Gm. 

Mix  the  saccharin  with  the  tincture  of  vanilla,  then  add 
thefcaffeine  and  finally  the  other  ingredients,  and  triturate 
until  they  are  thoroughly  mixed.  Compress  in  tablet  machine, 
using  3/8-inch  die  and  punches,  to  make  one  hundred  0.30  Gm. 
tablets. 


FORMULARY.  45 

16.  TABELLAE  CARBONIS  LIGNI   BULGES. 
Sweet  Tablets  of  Charcoal. 

0.18  Gm.  (gr.  3). 

Charcoal,  finely  powdered 18.00  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    3.00  Cc. 

Alcohol 15.00  Cc. 

Extract  of  glycyrrhiza,  powdered.  .  .  .    3.00  Gm. 

Spirit  of  anise,  10% 1.00  Cc. 

Spirit  of  coriander,  10% 0.50  Cc. 

Cacao  butter,  in  thin  shavings 1.50  Gm. 

Sugar,  powdered 7.50  Gm. 

Mix  all  the  ingredients  except  the  cacao  butter  by  thorough 
trituration  (in  a  warm  mortar  if  in  a  hurry),  permit  the 
alcohol  to  evaporate  completely;  then  incorporate  the  cacao 
butter  by  gentle  trituration  for  a  short  time  only.  Compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 


17.  TABELLAE  CERII  OXALATIS  DULCES. 
Sweet  Tablets  of  Cerium  Oxalate. 

0.12  Gm.  (gr.  2). 

Cerium  oxalate 12.00  Gm. 

Fat  starch 2.00  Gm. 

White  fat  sugar 16.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Cerium  oxalate 12.00  Gm. 

Spirit  of  peppermint 0.04  Cc. 

Fat  starch 5.00  Gm. 

Sugar,  powdered 13.00  Gm. 

Mix  the  cerium  oxalate,  the  powdered  sugar,  and  the  spirit 
of  peppermint  by  thorough  trituration  in  a  mortar;  add  the 
fat  starch  by  gentle  trituration  for  a  short  time  only;  and 
compress  in  a  tablet  machine,  using  3/8-inch  die  and  punches, 
to  make  one  hundred  0.30  Gm.  tablets. 


46  CANDY  MEDICATION. 

18.  TABELLAE  COCAINAE  DULCES. 

Sweet  Tablets  of  Cocaine. 

0.001  Gm.  (gr.  1/60). 

Caution: — Only  a  small  number  of  these  tablets  should  be 
ordered  at  one  time,  as  centigram  doses  have  produced 
lethal  results  in  children 

Cocaine  hydrochloride 0.10  Gm. 

Vanilla  cacao  sugar 30.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Cocaine  hydrochloride 0.10  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 27.00  Gm. 

Mix  the  cocaine  hydrochloride  and  sugar  by  trituration  in 
a  mortar;  then  add  the  cacao  and  the  tincture  of  vanilla, 
and  triturate  again  until  the  color  is  perfectly  uniform;  and 
compress  in  a  tablet  machine,  using  3/8-inch  die  and  punches, 
to  make  one  hundred  0.30  Gm.  tablets. 


19.  TABELLAE  CRETAE  DULCES. 
Sweet  Tablets  of  Chalk. 

0.12  Gm.  (gr.  2). 

Each  tablet  represents  approximately  one  half  teaspoonful 
of  the  official  chalk  mixture. 

Prepared  chalk 12.00  Gm. 

Fat  starch 3.00  Gm. 

Red  fat  sugar 10.00  Gm. 

Mix  by  thorough  trituration  in  mortar  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.25  Gm.  tablets. 


FORMULARY.  47 

Alternate  Formula. 

Prepared  chalk'. 12.00  Gm. 

Carmine 0.20  Gm. 

Spirit  of  cinnamon,  10% 0.15  Cc. 

Fat  starch 5.00  Gm. 

Sugar,  powdered 8.00  Gm. 

Mix  the  chalk,  the  flavoring,  and  the  coloring  with  the 
sugar  by  thorough  trituration  in  a  mortar,  until  the  pink 
color  is  perfectly  uniform;  then  add  the  fat  starch  by  gen- 
tle trituration  for  a  short  time  only;  and  compress  in  a  tablet 
machine,  using  a  3/8-inch  die  and  punches,  to  make  one  hun- 
dred 0.25  Gm.  tablets. 

20.  TABELLAE  DIGITALIS  BULGES. 
Sweet  Tablets  of  Digitalis. 

0.008  Gm.  (gr.  1/8). 

Caution: — Owing  to  the  toxicity  of  the  digitalis,  it  is  best 
not  to  order  more  than  a  limited  number  of  these  tablets  at 
one  time. 

Digitalis  powder 0.80  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    3.00  Cc. 

Liquid  petrolatum 0.30  Cc. 

Cinnamon  cacao  sugar 29.00  Gm. 

Mix  the  powdered  digitalis  with  the  alcoholic  solution  of 
saccharin  (in  a  warm  mortar  if  in  a  hurry)  and  permit  the 
alcohol  to  evaporate.  Then  add  the  liquid  petrolatum 
and  triturate.  Finally  incorporate  the  cacao  sugar  by 
thorough  trituration  in  a  mortar.  Compress  in  a  tablet 
machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred    0.30   Gm.    tablets. 

Alternate  Formula. 

Digitalis  powder 0.80  Gm. 

Alcoholic  solution  of  saccharin 3.00  Cc. 

Liquid  petrolatum 0.30  Cc. 

Spirit  of  cinnamon,  10% 0.15  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 26.00  Gm. 

Prepare  the  digitalis,  as  above  described.  Mix  it  with 
the  cacao,  the  sugar,  and  the  spirit  of  cinnamon  by  thorough 
trituration  in  a  mortar;  and  compress  in  a  tablet  machine, 
using  3/8-inch  die  and  punches,  to  make  one  hundred  0.30 
Gm.  tablets. 


4S  CANDY  MEDICATION. 

21.  TABELLAE  ELATERINI   DULCES. 

Sweet  Tablets  of  Elaterin. 

0.0006  Gm.  (gr.  1/100). 

Caution: — Only  a  small  number  of  these  tablets  should 
be  ordered  at  one  time. 

Elaterin  trituration,  10% 0.60  Gm. 

Red  fat  sugar 18.00  Gm. 

Thoroughly  triturate  the  elaterin  with  the  red  fat  sugar, 
added  in  portions,  and  make  one  hundred  0.18  Gm.  tablets 
by  compressing  in  a  tablet  machine,  using  5/16-inch  die  and 
punches. 

Alternate  Formula. 

Elaterin  trituration,  10% 0.60  Gm. 

Carmine 0.50  Gm. 

Spirit  of  cinnamon,  10% 0.20  Cc. 

Fat  starch 3.60  Gm. 

Sugar,  powdered 13.30  Gm. 

Having  thoroughly  mixed  the  elaterin  trituration  with 
sugar,  add  the  carmine  and  the  spirit  of  cinnamon,  and 
triturate  again  until  the  color  is  uniform.  Then  add  the 
fat  starch  by  gentle  trituration;  and  compress  in  a  tablet 
machine,  using  5/16-inch  die  and  punches,  to  make  one  hun- 
dred 0.18  Gm.  tablets. 

22.  TABELLAE  EMETINAE  DULCES. 

Sweet  Tablets  of  Emetine. 

0.0012  Gm.  (gr.  1/50). 

Caution: — Only  a  moderate  number  should  be  ordered 
at  one  time. 

Emetine 0.12  Gm. 

Sodium  bicarbonate 2.00  Gm. 

Vanilla  cacao  sugar 28.00  Gm. 

Mix  the  ingredients  by  thorough  trituration  in  a  mortar 
and  compress  in  a  tablet  machine,  using  3/8-inch  die  and 
punches,  to  make  one  hundred  0.30  Gm.  tablets. 

Note: — If  the  powder  does  not  work  well  in  the  machine, 
a  little  shaved  paraffin  added  by  gentle  trituration  will  over- 
come the  trouble. 


FORMULARY.  49 

Alternate  Formula. 

Emetine 0.12  Gm. 

Sodium  bicarbonate 2.00  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 25.00  Gm. 

Thoroughly  triturate  the  emetine  with  the  sugar  and 
sodium  bicarbonate;  then  add  the  cacao  powder  and  the  tinc- 
ture of  vanilla,  and  triturate  again  until  the  color  is  per- 
fectly uniform;  and  compress  in  a  tablet  machine,  using 
3/8-inch  die  and  punches,  to  make  one  hundred  0.30  Gm. 
tablets. 

Note: — See  note  under  above  formula. 


23.  TABELLAE  FERMENTI  ACIDI  LACTICI 
DULCES. 

Sweet  Tablets  of  Lactic  Acid  Ferment. 

0.06  Gm.  (gr.  1). 

Lactic  acid  ferment 6.00  Gm. 

Yellow  fat  sugar 24.00  Gm. 

Triturate  gently  in  a  mortar  and  compress  in  a  tablet 
machine,  using  3/8-inch  die  and  punches,  so  make  one  hun- 
dred 0.30  Gm.  tablets. 

Alternate  Formula. 

Lactic  acid  ferment 6.00  Gm. 

Spirit  of  lemon,  10% 1.25  Cc. 

Tincture  of  curcuma 2.50  Cc. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 18. 00  Gm. 

Mix  the  sugar  with  the  tincture  of  curcuma  and  the  spirit 
of  lemon  and  permit  the  alcohol  to  evaporate.  Then  thorough- 
ly incorporate  the  lactic  acid  ferment  by  gentle  trituration 
in  a  mortar.  Finally  add  the  fat  starch  by  gentle  trituration 
for  a  short  time  only;  and  compress  in  a  tablet  machine, 
using  3/8-inch  die  and  punches,  to  make  one  hundred  0.30 
Gm.  tablets. 


so  CANDY  MEDICATION. 

24.  TABELLAE  FERRI   CARBONATIS  DULCES. 

Sweet  Tablets  of  Ferrous  Carbonate. 

0.02  Gm.  (gr.  1/3). 

Saccharated  ferrous  carbonate. 13,50  Gm. 

Cinnamon  cacao  sugar. .  .  = 16.50  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Saccharated  ferrous  carbonate 13.50  Gm. 

Spirit  of  cinnamon,  10% 0.10  Cc. 

Cacao  powder 1.50  Gm. 

Sugar,  powdered 15.00  Gm. 

Mix  by  thorough  trituration;  and  compress  in  a  tablet 
machine,  using  3/8-inch  die  and  punches,  to  make  one  hun- 
dred 0.30  Gm.  tablets. 

25.  TABELLAE  FERRI  ET  ARSENI   DULCES. 
Sweet  Tablets  of  Iron  (0.02  Gm.),  and  Arsenic 

(0.0005  Gm.). 

Caution: — Only  a  moderate  number  of  these  tablets  should 
be  ordered  at  one  time. 

Arsenic  trioxide 0.06  Gm. 

Saccharated  ferrous  carbonate 13.50  Gm. 

Cinnamon  cacao  sugar 16.50  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Arsenic  trioxide 0.06  Gm. 

Saccharated  ferrous  carbonate 13.50  Gm. 

Spirit  of  cinnamon,  10% 0.10  Cc. 

Cacao  povv^der 1.50  Gm. 

Sugar,  powdered 15.00  Gm. 

Triturate  the  arsenic  trioxide  with  the  sugar,  added  in 
portions,  until  thoroughly  mixed.  Then  add  the  other 
ingredients;  triturate  again  until  the  color  is  perfectly  uni- 
form; and  compress  in  a  tablet  machine,  using  3/8-inch  die 
and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 


FORMULARY.  51 

26.  TABELLAE  FERRI   REDUCTI   DULCES. 
Sweet  Tablets  of  Reduced  Iron. 

0.06  Gm.  (gr.  1). 

Reduced  Iron 6.00  Gm. 

Vanilla  cacao  sugar 24.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Reduced  iron 6.00  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 2.50  Gm. 

Sugar,  powdered 21.50  Gm. 

Directions  same  as  above. 


27.  TABELLAE  FERRI,  QUININAE  ET  STRYCH- 
NINAE  DULCES. 

Sweet  Tablets  of  Iron,  Quinine  and  Strychnine. 

Equivalent  to  about  1  Cc.  ot  Elixir  of  Iron,  Quinine  and 
Strychnine. 

Caution: — Only  a  moderate  number  of  these  tablets  should 
be  ordered  at  one  time. 

Alcresta  strychnine,  5% 0.54  Grn. 

Lloyd's  Reagent. 1.00  Gm. 

Aristochin 1.00  Gm. 

Saccharated   ferrous  carbonate 3.33  Gm. 

Saccharin 0.10  Gm. 

Cinnamon  cacao  sugar 24.03  Gm. 

Mix  the  ingredients  by  thorough  trituration  in  a  mortar 
and  compress  in  a  tablet  machine,  using  3/8-inch  die  and 
punches,   to  make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Alcresta  strychnine,  5% 0.54  Gm. 

Lloyd's  Reagent 1.00  Gm. 

Aristochin 1.00  Gm. 

Saccharated  ferrous  carbonate 5.33  Gm. 

Saccharin 0. 10  Gm. 

Spirit  of  cinnamon,  10% 0.15  Cc. 

Cacao  powder 2.50  Gm. 

Sugar,  powdered 21.53  Gm. 


52  CANDY  MEDICATION. 

Mix  the  spirit  of  cinnamon  with  the  sugar,  and  set  aside. 
Mix  the  other  ingredients  by  thorough  trituration  in  a  mortar; 
and  finally  incorporate  the  flavored  sugar.  Compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

28.  TABELLAE  GLYCERYLIS  NITRATIS  BULGES. 
Sweet  Tablets  of  Nitroglycerin. 

0.0003  Gm.  (gr.  1/200). 

Caution: — Only  a  small  number  of  these  tablets  should  be 
ordered  at  one  time. 

These  tablets  do  not  keep  well,  hence  should  be  freshly 
prepared  when  wanted. 

Larger  doses  might  be  administered  in  this  form. 

Spirit  of  nitroglycerin,    1% 3.00  Cc. 

Red  fat  sugar 18.00  Gm. 

Triturate  the  spirit  of  nitroglycerin  with  the  red  fat 
sugar  and  permit  the  alcohol  to  evaporate.  When  thoroughly 
dry,  compress  in  a  tablet  machine,  using  5/16-inch  die  and 
punches,  to  make  one  hundred  0.18  Gm.  tablets. 

Alternate  Formula. 

Spirit  of  nitroglycerin,  1% 3.00  Cc. 

Spirit  of  cinnamon,  10% 0.20  Cc. 

Carmine 0.50  Gm. 

Fat  starch 3.60  Gm. 

Sugar,  powdered 14.40  Gm. 

Triturate  the  carmine  with  the  spirit  of  cinnamon  and  the 
sugar,  until  the  color  is  perfectly  uniform.  Then  add  the 
spirit  of  nitroglycerin,  and  triturate  again  thoroughly  but 
gently.  Finally  incorporate  the  fat  starch  by  gentle  tri- 
turation for  a  short  time  only;  and  compress  in  a  tablet  ma- 
chine, using  5/16-inch  die  and  punches,  to  make  one  hundred 
0.18  Gm.  tablets. 

29.  TABELLAE  HEROINAE  DULCES. 
Sweet  Tablets  of  Heroine. 

0.0006  Gm.  (gr.  1/100). 

Caution: — Owing  to  the  toxicity  of  heroine  only  a  small 
number  of  these  tablets  should  be  ordered  at  one  time. 


FORMULARY.  SA 

Heroine  hydrochloride 0.06  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    2.00  Cc. 

Sodium  bicarbonate 1.00  Gm. 

Vanilla  cacao  sugar 29.00  Gm. 

Mix  the  heroine  hydrochloride  with  the  alcoholic  solution 
of  saccharin  (in  a  hot  mortar  if  in  a  hurry)  and  permit  the 
alcohol  to  evaporate;  then  add  the  vanilla  cacao  sugar. 
Triturate  thoroughly;  and  compress  in  a  tablet  machine, 
using  3/8-inch  die  and  punches,  to  make  one  hundred 
0.30  Gm.  tablets. 

Note: — If  any  difficulty  is  found  in  the  compressing  of 
these  tablets,  the  addition  of  a  small  amount  of  shaved 
paraffin  will  overcome  it. 

Alternate  Formula. 

Heroine  hydrochloride 0.06  Gm. 

Saccharin 0.06  Gm. 

Sodium  bicarbonate 1.00  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 26.00  Gm. 

Mix  the  saccharin  with  the  tincture  of  vanilla;  then  add 
the  heroine  hydrochloride.  Permit  the  alcohol  to  evaporate. 
Thoroughly  triturate  with  the  sugar,  added  in  portions. 
Finally  add  the  sodium  bicarbonate  and  the  cacao  powder; 
and  triturate  again  until  the  color  is  uniform.  Compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Note: — See  note  under  above  formula. 


30.  TABELLAE  HEXAMETHYLENAMINAE  DULCES 
Sweet  Tablets  of  Hexamethylenamine  (Urotropin). 

0.03  Gm.  (gr.  1/2). 
As  much  as  0.06  Gm.  (gr.  1  )may  be  given  in  this  form. 

Hexamethylenamine 3.00  Gm. 

Vanilla  cacao  sugar 27.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 


54  CANDY   MEDICATION. 

Alternate  Formula. 

Hexamethylenamine 3.00  Gm. 

Tincture  of  vanilla 1,50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 24.00  Gm. 

Directions,  same  as  above. 

31.   TABELLAE  HYDRARGYRI  CHLORIDI 
MITIS  DULCES. 

Sweet  Tablets  of  Mild  Mercurous  Chloride  (Calomel). 

0.006  Gm.  (Gr.  1/10). 

Much  larger  dose  could  be  administered  in  this  form. 

Mild  mercurous  chloride 0.60  Gm. 

Pink  fat  sugar 17.40  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress  in 
a  tablet  machine,  using  5/16-inch  die  and  punches,  to  make 
one  hundred  0.18  Gm.  tablets. 

Alternate  Formula. 

Mild  mercurous  chloride 0.60  Gm. 

Carmine 0. 10  Gm. 

Spirit  of  rose,  1% 0.40  Cc. 

Fat  starch 3.60  Gm. 

Sugar,  powdered 14.40  Gm. 

Having  thoroughly  triturated  the  mild  mercurous  chloride 
with  the  sugar,  add  the  carmine  and  the  spirit  of  rose;  and 
triturate  again  until  the  pink  color  is  perfectly  uniform. 
Then  add  the  fat  starch  by  triturating  gently  and  for  a 
short  time  only.  Compress  in  a  tablet  machine,  using  5/16- 
inch  die  and  punches,  to  make  one  hundred  0.18  Gm.  tablets. 

32.  TABELLAE  HYDRARGYRI  CUM  CRETA  DULCES. 
Sweet  Tablets  of  Mercury  with  Chalk. 

0.03  Gm.  (gr.  1/2.). 
Larger  dose  could  be  administered  in  this  form. 

Mercury  with  chalk 3.00  Gm. 

White  fat  sugar 27.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 


FORMULARY.  55 

Alternate  Formula. 

Mercury  with  chalk 3.00  Gm. 

Spirit  of  peppermint 0.60  Cc. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 2 1. 00  Gm. 

Mix  the  ingredients,  with  the  exception  of  the  fat 
starch,  by  thorough  trituration  in  a  mortar;  add  the  latter 
by  gentle  trituration  for  a  short  time  only;  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to 
make  one  hundred  0.30  Gm.  tablets. 


33.  TABELLAE  HYDRARGYRI  lODIDI 
FLAVI   BULGES. 

Sweet  Tablets  of  Yellow  Mercurous  Iodide. 

0.003  Gm.  (gr.  1/20). 

Larger  dose  could  be  administered  in  this  form. 

These  tablets  must  be  well  protected  against  lightTorJthey 
will  rapidly  become  dark;  when  thus  protected,  they  keep 
fairly  well. 

Yellow  mercurous  iodide 0.30  Gm. 

White  fat  sugar 18.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress  in 
a  tablet  machine,  using  5/16-inch  die  and  punches,  to  make 
one  hundred  0.18  Gm.  tablets. 

Alternate  Formula. 

Yellow  mercurous  iodide 0.30  Gm. 

Spirit  of  peppermint 0.40  Cc. 

Fat  starch 3.60  Gm. 

Sugar,  powdered 14. 10  Gm. 

Having  thoroughly  triturated  the  yellow  mercurous 
iodide  with  the  sugar,  add  the  spirit  of  peppermint  and  tri- 
turate again.  Then  add  the  fat  starch,  triturating  gently 
and  for  a  short  time  only.  Compress  in  a  tablet  machine, 
using  5/16-inch  die  and  punches,  to  make  one  hundred  0.18 
Gm.  tablets. 


56  CANDY  MEDICATION. 

34.    TABELLAE    HYDRARGYRI    lODIDI    RUBRI 

DULCES. 

Sweet  Tablets  of  Red  Mercuric  Iodide. 

0.001  Gm.  (gr.  1/60). 

Caution: — Only  a  moderate  number  of  these  tablets  should 
be  ordered  at  one  time. 

Larger  dose  of  red  mercuric  iodide  could  be  administered 
in  this  form. 

Red  mercuric  iodide 0.10  Gm. 

Red  fat  sugar 18.00  Gm. 

Thoroughly  mix  the  red  mercuric  iodide  with  the  red 
fat  sugar  by  trituration  in  a  mortar;  and  compress  in  a  tablet 
machine,  using  5/16-inch  die  and  punches,  to  make  one 
hundred  0.18  Gm.  tablets. 

Alternate  Formula. 

Red  mercuric  iodide 0.10  Gm. 

Spirit  of  cinnamon,  10% 0. 20  Cc. 

Carmine 0.50  Gm. 

Fat  starch ,  .    3. 60  Gm. 

Sugar,  powdered 13.80  Gm. 

Having  thoroughly  triturated  the  red  mercuric  iodide  with 
the  sugar,  add  the  carmine  and  the  spirit  of  cinnamon  and 
triturate  again.  Then  add  the  fat  starch,  triturating  gently 
and  for  a  short  time  only.  Compress  in  a  tablet  machine, 
using  5/16-inch  die  and  punches,  to  make  one  hundred  0.18 
Gm.  tablets. 

35.  TABELLAE  HYOSCINAE  DULCES. 
Sweet  Tablets  of  Hyoscine. 

0.00006  Gm.  (gr.  1/1000). 

Much  larger  dose  could  be  administered  in  this  form,  e.  g., 
0.0006  Gm.  (gr.  1/100)  per  tablet. 

Caution: — Only  a  small  number  of  these  tablets  should  be 
ordered  at  one  time. 

Hyoscine  hydrobromide 0.006  Gr. 

Red  fat  sugar 18.00  Gm. 

Triturate  the  hyoscine  hydrobromide  with  red  fat  sugar, 
added  in  portions,  and  compress  in  a  tablet  machine,  using 
5/16-inch  die  and  punches,  to  make  one  hundred  0.18  Gm. 
tablets. 


FORMULARY.  57 

Alternate  Formula. 

Hyoscine  hydrobromide 0.006  Gm. 

Carmine '. 0.50    Gm. 

Spirit  of  cinnamon,  10% 0.20    Cc. 

Fat  starch 3.60     Gm. 

Sugai,  powdered 14.00    Gm. 

Having  thoroughly  triturated  the  hyoscine  hydrobromide 
with  the  sugar,  add  spirit  of  cinnamon  and  the  carmine,  and 
triturate  again  until  the  color  is  perfectly  uniform.  Then 
add  the  fat  starch,  triturating  gently  and  for  a  short 
time  only.  Compress  in  a  tablet  machine,  using  5/16-inch 
die  and  punches,  to  make  one  hundred  0.18  Gm.  tablets. 

36.   TABELLAE   IPECACUANHAE  ET  OPII   DULCES. 
Sweet  Tablets  of  Ipecac  and  Opium  (Dover's  Powder). 

0.03  Gm.  (gr.  1/2). 

Caution: — Owing  to  the  toxicity  of  opium,  only  a  small 
number  shouM  be  ordered  at  one  time. 

Powdered  ipecac 0.30  Gm. 

Deodorized  opium 0.30  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    2.00  Cc. 

Sodium  bicarbonate 2.00  Gm. 

Cinnamon  cacao  sugar 27.40  Gm. 

Mix  the  ipecac  with  the  opium  and  the  alcoholic  solution 
of  saccharin  (in  a  warm  mortar  if  in  a  hurry)  and  permit 
the  alcohol  to  evaporate;  then  add  the  other  ingredients, 
triturate  thoroughly;  and  compress  in  a  tablet  machine, 
using  3/8-inch  die  and  punches,  to  make  one  hundred  0.30 
Gm.  tablets. 

Note: — If  any  difficulty  is  experienced  in  the  compression 
of  these  tablets,  the  addition  of  a  little  shaved  paraffin  will 
probably  remedy  it. 

Alternate  Formula. 

Powdered  ipecac 0.30  Gm. 

Deodorized  opium 0.30  Gm. 

Alcoholic  solution  of  saccharin,  3%.  .  2.00  Cc. 

Spirit  of  cinnamon 0.15  Cc. 

Sodium  bicarbonate 2.00  Gm. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 24.40  Gm. 

Directions,  same  as  above. 


58  CANDY  MEDICATION. 

37.   TABELLAE   MAGNESII   OXIDI    DULCES. 
Sweet  Tablets  of  Magnesia. 

0.06  Gm.  (gr.  1). 

The  dose  may  seem  small;  it  represents,  however,  1/3 
teaspoonful  of  Magnesia  Magma  (Milk  of  Magnesia)   N.  F. 

Heavy  Magnesium  oxide 6.00  Gm. 

Saccharin 0.03  Gm. 

Spirit  of  peppermint 0.60  Cc. 

Fat  starch 5. 00  Gm. 

Sugar,  powdered 14.00  Gm. 

Mix  the  saccharin  with  the  spirit  of  peppermint,  add  the 
magnesia,  and  mix  by  thorough  trituration  in  a  mortar. 
Then  incorporate  the  sugar  by  thorough  trituration,  and  fat 
starch  by  gentle  trituration  for  a  short  time  only.  Com- 
press in  a  tablet  machine,  using  3/8-inch  die  and  punches, 
to  make  one  hundred  0.25   Gm.  tablets. 

38.    TABELLAE    MAGNESII    SALICYLATIS    DULCES. 
Sweet  Tablets  of  Magnesium  Salicylate. 

0.03  Gm.  (gr.  1/2). 

Magnesium  salicylate 3.00  Gm. 

Green  fat  sugar 27.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar,  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Magnesium  salicylate 3.00  Gm. 

Spirit  of  gaultheria,  10% 1.20  Cc. 

Solution  of  malachite  green,  1:1000..   1.20  Cc. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 2 1. 00  Gm. 

Mix  the  ingredients,  excepting  the  fat  starch,  by  thor- 
ough trituration  in  a  mortar;  incorporate  the  fat  starch  by 
gentle  trituration  for  a  short  time  only;  and  compress  in  a 
tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 


FORMULARY. 


59 


39.  TABELLAE  MORPHINAE  DULCES. 
Sweet  Tablets  of  Morphine. 

0.0006  Gm.  (gr.  1/100). 

Caution: — Owing  to  the  toxicity  of  morphine  only  a  few 
of  these  tablets  should  be  ordered  at  one  time,  perhaps  not 
more  than  three,  as  a  few  milligrams  are  liable  to  constitute 
a  lethal  dose. 

Morphine  (alkaloid) 0.06  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    2.00  Cc. 

Sodium  bicarbonate 1.00  Gm. 

Vanilla  cacao  sugar 29.00  Gm. 

Mix  the  morphine  with  the  alcoholic  solution  of  saccharin 
(in  a  hot  mortar  if  in  a  hurry),  and  permit  the  alcohol  to 
evaporate;  then  add  the  sodium  bicarbonate  and  the  vanilla 
cacao  sugar,  triturating  thoroughly;  and  compress  in  a  tablet 
machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 

Note: — If  any  difficulty  is  experienced  in  the  compression 
of  these  tablets,  the  addition  of  a  little  shaved  paraffin  will 
probably  remedy  it. 


Alternate  Formula. 

Morphine  (alkaloid) 

Saccharin 

Tincture  of  vanilla. 
Sodium  bicarbonate 

Cacao  powder 

Sugar,  powdered. . . 


0.06:Gm. 
0.06  Gm. 
1.50?Cc. 
1.00;Gm. 
3.00Gm. 
26.00rGm. 


Mix  the  saccharin  with  the  tincture  of  vanilla,  add  the 
morphine,  and  allow  the  alcohol  to  evaporate.  Then  in- 
corporate the  other  ingredients  by  thorough  trituration|^in 
a  mortar;  and  compress  in  a  tablet  machine,  using  3/8-inch 
die  and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 

Note: — See  note  under  above  formula. 


40.  TABELLAE  PHENOLPHTHALEINI   DULCES. 
Sweet  Tablets  of  Phenolphthalein. 

0.06  Gm.  (gr.  1). 

Phenolphthalein 6.00  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    4.00  Cc. 
Vanilla  cacao  sugar 24.00  Gm. 


60  CANDY  MEDICATION. 

Mix  the  phenolphthalein  with  the  alcoholic  solution  of 
saccharin  (in  a  hot  mortar  if  in  a  hurry),  and  permit  the  al- 
cohol to  evaporate.  Then  add  the  vanilla  cacao  sugar. 
Mix  thoroughly  and  compress  in  a  tablet  machine,  using  3/8- 
inch  die  and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Phenolphthalein 6.00  Gm. 

Saccharin 0.12  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 2 1.00  Gm. 

Mix  the  saccharin  with  the  tincture  of  vanilla,  and  incor- 
porate the  phenolphthalein.  Finally  add  the  sugar  and  the 
cacao  by  thorough  trituration  in  a  mortar.  Compress  in  a 
tablet  machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 


41.  TABELLAE  PILOCARPINAE  DULCES. 
Sweet  Tablets  of  Pilocarpine. 

0.0012  Gm,  (gr.  1/50). 

Caution: — Only  a  moderate  number  of  these  tablets 
should  be  ordered  at  one  time. 

Pilocarpine  hydrochloride 0.12  Gm. 

Vanilla  cacao  sugar 30.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar;  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Pilocarpine  hydrochloride 0.12  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 27.00  Gm. 

Mix  the  pilocarpine  hydrochloride  with'fthe  sugar  by 
thorough  trituration  in  a  mortar,  add  the  cacao  powder  and 
triturate  again  until  the  color  is  perfectly  uniform.  Finally 
incorporate  the  tincture  of  vanilla  and  compress  in  a  tablet 
machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 


FORMULARY.  «1 

42.  TABELLAE  RESINAE  JALAPAE  DULCES. 
Sweet  Tablets  of  Resin  of  Jalap. 

0.03  Gm.  (gr.  1/2). 

Caution: — Only  a  small  number  of  these  tablets  should 
be  ordered  at  one  time. 

Resin  of  jalap 3.00  Gm. 

Cinnamon  cacao  sugar 27.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar;  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Resin  of  jalap 3.00  Gm. 

Spirit  of  cinnamon,  10% 0.20  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 24.00  Gm. 

Mix  the  resin  of  jalap,  the  cacao,  and  the  sugar  by  thor- 
ough trituration  in  a  mortar;  finally  incorporate  the  spirit 
of  cinnamon;  and  compress  in  a  tablet  machine,  using  3/8- 
inch  die  and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 

43.  TABELLAE  RESINAE  PODOPHYLLI   DULCES 
Sweet  Tablets  of  Resin  of  Podophyllum. 

0.001  Gm.  (gr.  1/60). 

Caution: — Only  a  small  number  of  these  tablets  should  be 
ordered  at  one  time. 

Citric  acid 0.05  Gm. 

Resin  of  podophyllum 0.10  Gm.  ^ 

Alcoholic  solution  of  saccharin,  3%. .    2.00  Cc. 
Cinnamon  cacao  sugar 30.00  Gm. 

Mix  the  re?in  of  podophyllum  and  the  citric  acid  with  the 
alcoholic  solution  of  saccharin  and  permit  the  alcohol  to 
evaporate.  Add  the  cinnamon  cacao  sugar;  triturate  thor- 
oughly; and  compress  in  a  tablet  machine,  using  3/8-inch 
die  and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 


62  CANDY   MEDICATION. 

Alternate  Formula. 

Citric  acid 0.05  Gm. 

Resin  of  podophyllum 0.10  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    2.00  Cc. 

Spirit  of  cinnamon,  10% 0.20  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 27.00  Gm. 

Directions,  same  as  above. 

44.  TABELLAE  SABROMINI  DULCES. 
Sweet  Tablets  of  Sabromin. 

0.06  Gm.  (gr.  1). 

Sabromin 6.00  Gm. 

Pink  fat  sugar 24.00  Gm. 

Mix  the  sabromin  with  the  pink  fat  sugar  by  thorough 
trituration  in  a  mortar.  Compress  in  a  tablet  machine,  with 
rather  heavy  pressure,  using  3/8-inch  die  and  punches,  to 
make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Sabromin 6.00  Gm. 

Spirit  of  rose,  1% 0.60  Cc. 

Carmine 0. 20  Gm. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 18.00  Gm. 

Mix  the  Sabromin  with  the  carmine  and  the  sugar,  add  the 
spirit  of  rose,  and  triturate  until  thoroughly  mixed.  Finally 
incorporate  the  fat  starch;  and  compress  in  tablet  machine, 
with  rather  heavy  pressure,  using  3/8-inch  die  and  punches, 
tofmake  one  hundred  0.30  Gm.  tablets. 


45.  TABELLAE  SAJODINI  DULCES. 
Sweet  Tablets  of  Sajodin. 

0.06  Gm.  (gr.  1). 

Sajodin 6.00  Gm. 

Pink  fat  sugar 24.00  Gm. 


FORMULARY.  63 

Mix  the  sajodin  with  the  pink  fat  sugar  by  thorough 
trituration  in  a  mortar.  Compress  in  a  tablet  machine, 
with  rather  heavy  pressure,  using  3/8-inch  die  and  punches, 
to  make  one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Sajodin 6.00  Gm. 

Spirit  of  rose,  1% 0.60  Cc. 

Carmine 0. 20  Gm. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 18.00  Gm. 

Mix  the  sajodin  with  the  carmine  and  the  sugar,  add  the 
spirit  of  rose,  and  triturate  until  thoroughly  mixed.  Finally 
incorporate  the  fat  starch;  and  compress  in  tablet  machine, 
with  rather  heavy  pressure,  using  3/8-inch  die  and  punches, 
to^make  one  hundred  0.30  Gm.  tablets. 


46.  TABELLAE  SALOQUININAE  DULCES. 
Sweet  Tablets  of  Saloquinine. 

0.06  Gm.  (gr.  1). 

Saloquinine 6.00  Gm. 

Green  fat  sugar 24.00  Gm. 

Mix  the  saloquinine  with  the  green  fat  sugar  by  thorough 
trituration  in  a  mortar;  and  compress  in  a  tablet  machine, 
using  3/8-inch  die  and  punches,  to  make  one  hundred  0.30 
Gm.  tablets. 

Alternate  Formula. 

Saloquinine 6.00  Gm. 

Spirit  of  gaultheria,  10% 1.00  Cc. 

Solution  of  malachite  green,  1:1000..   1.00  Cc. 

Fat  starch 6.00  Gm. 

Sugar,  powdered 18.00  Gm. 

Mix  the  saloquinine  and  the  sugar,  the  coloring  and  the 
flavoring  by  thorough  trituration  in  a  mortar;  incorporate 
the  fat  starch  by  gentle  trituration;  and  compress  in  a 
tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 


64  CANDY  MEDICATION. 

47.  TABELLAE  SANTONINI   DULCES 
Sweet  Tablets  of  Santonin. 

0.03  Gm.  (gr.  1/2). 

Caution: — Only  a  small  number  of  these  tablets  should  be 
ordered  at  one  time,  perhaps  not  more  than  three,  as  0.13 
Gm.  has  caused  the  death  of  a  child. 

Santonin 3.00  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    2.00  Cc. 
Vanilla  cacao  sugar 27.00  Gm. 

Mix  the  alcoholic  solution  of  saccharin  with  the  santonin 
(in  a  hot  mortar  if  in  a  hurry)  and  permit  the  alcohol  to 
evaporate.  Then  mix  thoroughly  with  the  vanilla  cacao 
sugar;  and  compress  in  a  tablet  machine,  using  3/8-inch  die 
and  punches,  to  make  one  hundred  0.30  Gm,  tablets. 

Alternate  Formula. 

Santonin 3.00  Gm. 

Saccharin 0.06  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 24.00  Gm. 

Mix  the  saccharin  with  the  tincture  of  vanilla,  add  the 
santonin,  and  permit  the  alcohol  to  evaporate.  Then  mix 
with  the  sugar  and  the  cacao  by  thorough  trituration  in  a 
mortar.  Compress  in  a  tablet  machine,  using  3/8-inch  die 
and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 

48.  TABELLAE  SENNAE  DULCES. 
Sweet  Tablets  of  Senna. 

0.06  Gm.  (gr.  1). 

Senna,  powdered 6.00  Gm. 

Alcoholic  solution  of  saccharin,  3%.  .    2.00  Cc. 

Paraffin,  in  thin  shavings 1.50  Gm. 

Yellow  fat  sugar 22.50  Gm. 

Pour  the  alcoholic  solution  of  saccharin  over  the  senna 
and  permit  the  alcohol  to  evaporate  completely.  (Dry 
saccharinization,  using  0.06  Gm.  of  saccharin,  is  slightly  less 
efficient;  but  may  be  used  for  extemporaneous  preparations.) 


FORMULARY.  65 

Incorporate  the  yellow  fat  sugar  by  thorough  trituration 
in  a  mortar;  and  finally  the  paraffin  by  gentle  trituration 
for  a  short  time  only.  Compress  in  a  tablet  machine,  using 
3/8-inch  die  and  punches,  to  make  one  hundred  0.30  Gm. 
tablets. 

Alternate  Formula. 

Senna,  powdered 6.00  Gm. 

Saccharin 0.06  Gm. 

Spirit  of  lemon,  10% 0.15  Cc. 

Tincture  of  curcuma 3.00  Cc. 

Fat  starch 6. 00  Gm. 

Sugar,  powdered 18.00  Gm. 

Mix  the  saccharin  with  the  senna,  add  the  sugar  and  tri- 
turate thoroughly  until  well  mixed.  Then  add  the  spirit 
of  lemon  and  the  tincture  of  curcuma,  and  permit  the  alcohol 
to  evaporate  and  the  powder  to  dry  completely.  Finally 
incorporate  the  fat  starch  by  gentle  trituration  for  a  short 
time  only.  Compress  in  a  tablet  machine,  using  3/8-inch 
die  and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 

49.  TABELLAE  SODII  BICARBONATIS  DULCES. 
Sweet  Tablets  of  Sodium  Bicarbonate. 

0.06  Gm.  (gr.  1). 

Sodium  bicarbonate 6.00  Gm. 

Spirit  of  peppermint 0.60  Cc. 

Fat  starch 6. 00  Gm. 

Sugar,  powdered 18. 00  Gm. 

Mix  the  sodium  bicarbonate  with  the  sugar  and  the  spirit 
of  peppermint  by  thorough  trituration  in  a  mortar.  Then 
incorporate  fat  starch  by  gentle  trituration  for  a  short  time 
only;  and  compress  in  a  tablet  machine,  using  3/8-inch  die 
and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 

50.  TABELLAE  STROPHANTHINI  DULCES. 

Sweet  Tablets  of  Strophanthin. 

0.00003  Gm.  (gr.  1/2000). 

Caution: — Only  a  small  number  of  these  tablets  should  be 
ordered  at  one  time. 

Strophanthin  trituration,  10% 0.03  Gm. 

Alcoholic  solution  of  saccharin,  3%. .    2.00  Cc. 
Vanilla  cacao  sugar 30.00  Gm. 


66  CANDY  MEDICATION. 

Mix  the  strophanthin  trituration  with  alcoholic  solution 
of  saccharin  (in  a  hot  mortar  if  in  a  hurry);  and  permit  the 
alcohol  to  evaporate.  Add  the  vanilla  cacao  sugar  and  tri- 
turate thoroughly.  Compress  in  a  tablet  machine,  using 
3/8-inch  die  and  punches,  to  make  one  hundred  0.30  Gm. 
tablets. 

Alternate  Formula. 

Strophanthin  trituration,  10% 0.03  Gm. 

Saccharin 0.06  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 27.00  Gm. 

Mix  the  saccharin  with  the  tincture  of  vanilla,  add  the 
strophanthin,  and  permit  the  alcohol  to  evaporate.  Mix 
with  the  sugar  by  thorough  trituration  in  a  mortar;  and  in- 
corporate the  cacao  powder,  triturating  until  thoroughly 
mixed  and  the  color  is  uniform.  Compress  in  a  tablet  ma- 
chine, using  3/8-inch  die  and  punches,  to  make  one  hundred 
0.30  Gm.  tablets. 

51.  TABELLAE  ALCRESTA  STRYCHNINAE  DULCES. 
Sweet  Tablets  of  Alcresta  Strychnine. 

0.0003  Gm.  (gr.  1/200). 

Caution: — Only  a  small  number  of  these  tablets  should 
be  ordered  at  one  time,  probably  not  more  than  ten,  as  four 
milligrams  have  been  lethal  to  a  child. 

Citric  acid 0.06  Gm. 

Alcresta  strychnine,  5% 0.60  Gm. 

Saccharin 0. 10  Gm. 

Cinnamon  cacao  sugar 29.30  Gm. 

Mix  the  citric  acid,  alcresta  strychnine  and  saccharin  by 
thorough  trituration  in  a  mortar.  Add  the  cinnamon  cacao 
sugar  in  portions  and  triturate  thoroughly.  Compress  in  a 
tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Citric  acid 0.06  Gm. 

Alcresta  strychnine,  5% 0.60  Gm. 

Saccharin 0. 10  Gm. 

Spirit  of  cinnamon,  10% 0.15  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 26.30  Gm. 


FORMULARY.  67 

Mix  the  spirit  of  cinnamon  with  the  sugar;  permit  the  al- 
cohol to  evaporate.  In  another,  mortar  mix  the  citric  acid, 
the  alcresta  strychnine,  and  the  saccharin;  add  the  flavored 
sugar  in  portions,  and  triturate  until  thoroughly  mixed; 
finally  add  the  cacao  powder,  and  triturate  again  until  the 
color  is  uniform.  Compress  in  a  tablet  machine,  using  3/8- 
inch  die  and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 


52.  TABELLAE  SULPHONMETHANI  DULCES. 
Sweet  Tablets  of  Sulphonmethane. 

0.03  Gm.  (gr.  1/2). 

Caution: — Only  a  moderate  number  of  these  tablets  should 
be  ordered  at  one  time. 

Sulphonmethane 3.00  Gm. 

Alcoholic  solution  of  saccharin,  3%.  .    2.00  Cc. 

Liquid  petrolatum 1.00  Cc. 

White  fat  sugar 27.00  Gm. 

Mix  the  sulphonmethane  with  the  alcoholic  solution  of 
saccharin  (in  a  hot  mortar  if  in  a  hurry)  and  permit  the 
alcohol  to  evaporate.  Add  the  liquid  petrolatum  and  triturate 
again.  Finally  add  the  white  fat  sugar  and  compress  in  a 
tablet  machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Sulphonmethane 3.00  Gm. 

Saccharin 0.06  Gm. 

Liguid  petrolatum 1.00  Cc. 

Spirit  of  peppermint 0.60  Cc. 

Fat  starch 3.00  Gm. 

Sugar,  powdered 23.00  Gm. 

Mix  the  saccharin  with  the  spirit  of  peppermint  and  the 
sulphonmethane.  Allow  the  alcohol  to  evaporate.  Add  the 
liquid  petrolatum  and  triturate  again.  Incorporate  the  sugar 
by  thorough  trituration  in  a  mortar;  add  the  fat  starch, 
triturating  gently  and  for  a  short  time  only.  Compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches  to  make 
one  hundred  0.30  Gm.  tablets. 


68  CANDY  MEDICATION. 

53.  TABELLAE  SULPHURIS  DULCES. 
Sweet  Tablets  of  Sulphur. 

0.06  Gm.  (gr.  1). 

Precipitated  sulphur 6.00  Gm. 

Cinnamon  cacao  sugar 24.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar;  and  compress 
In  a  tablet  machine,  using  3/8-inch^die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Precipitated  sulphur 6.00  Gm. 

Spirit  of  cinnamon,  10% 0.15  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 21.00  Gm. 

Directions,  same  as  above. 

54.  TABELLAE  TANNALBINI  DULCES. 
Sweet  Tablets  of  Tannalbin. 

0.06  Gm.  (gr.  1). 

Tannalbin 6.00  Gm. 

Vanilla  cacao  sugar 19.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar,  and  compress 
in  a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.25  Gm.  tablets. 

Alternate  Formula. 

Tannalbin 6.00  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 2.00  Gm. 

Sugar,  powdered 17.00  Gm. 

Directions,  same  as  above. 

55.    TABELLAE    TERPINI    HYDRATIS    DULCES. 

Sweet  Tablets  of  Terpin  Hydrate. 

0.03  Gm.  (gr.  1/2). 

Represents  half-teaspoonful  of  the  Elixir  of  Terpin  Hy- 
drate, N.  F.,  in  a  much  more  pleasant  form. 

Terpin  Hydrate 3.00  Gm: 

Vanilla  Cacao  Sugar 27.00  Gm: 


FORMULARY.  69 

Mix  by  thorough  trituration  in  a  mortar  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm',  tablets. 

Alternate  Formula. 

Terpin  hydrate 3.00  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 24.00  Gm. 

Mix  the  cacao,  the  sugar,  and  the  tincture  of  vanilla,  and 
allow  the  alcohol  to  evaporate.  Add  the  terpin  hydrate; 
and  compress  in  a  tablet  machine,  using  3/8-inch  die  and 
punches,  to  make  one  hundred  0.30  Gm.  tablets. 


56.  TABELLAE  TERPINI  HYDRATIS  CUM  HEROINA 

BULGES. 

Sweet  Tablets  of  Terpin  Hydrate   (0.03   Gm.) 
with  Heroine.     0.0006  Gm.  (gr.  1/100). 

Represents  a  half-teaspoonful  of  the  N.  F.  Elixir  with  but 
half  the  amount  of  heroine  in  a  much  more  pleasant  form. 

Caution: — Only  a  small  number  of  these  tablets  should  be 
ordered  at  one  time. 

Heroine  hydrochloride 0.06  Gm. 

Alcoholic  solution  of  saccharin,  3%.  .    2.00  Cc. 

Terpin  hydrate 3.00  Gm. 

Vanilla  cacao  sugar 27.00  Gm. 

Mix  the  heroine  hydrochloride  with  the  alcoholic  solution 
of  saccharin  (in  a  hot  mortar  if  in  a  hurry),  and  permit  the 
alcohol  to  evaporate.  Add  the  terpin  hydrate  and  the 
vanilla  cacao  sugar;  triturate  thoroughly;  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Heroine  hydrochloride 0.06  Gm. 

Saccharin 0.06  Gm. 

Tincture  of  vanilla 1.50  Cc. 

Terpin  hydrate 3.00  Gm. 

Cacao  powder 3.00  Gm. 

Sugar,  powdered 24.00  Gm. 


70  CANDY  MEDICAf ION. 

Mix  the  heroine  hydrochloride  with  the  saccharin  and  the 
tincture  of  vanilla,  and  allow  alcohol  to  evaporate.  Mix 
with  the  sugar,  added  in  portions.  Finally  incorporate  the 
terpin  hydrate  and  the  cacao  powder  by  thorough  tritura- 
tion; and  compress  in  a  tablet  machine,  using  3/8-inch  die 
and  punches,  to  make  one  hundred  0.30  Gm.  tablets. 


57.  TABELLAE  THEOBROMINAE  SODIO- 
SALICYLATIS  DULCES. 

Sw^et    Tablets    of    Theobromine    Sodio -salicylate 

(Diuretin). 

0.015  Gm.  (gr.  1/4). 

Theobromine  sodio-salic^date 1.50  Gm. 

Alcoholic  solution  of  saccharin,  3%.  .    2.00  Cc. 

Liquid  petrolatum 0.50  Cc. 

White  fat  sugar 28.00  Gm. 

Mix  the  diuretin  with  the  alcoholic  solution  of  saccharin 
(in  a  hot  mortar  if  in  a  hurry),  and  permit  the  alcohol  to 
evaporate.  Add  the  liquid  petrolatum  and  triturate.  Finally 
incorporate  the  white  fat  sugar,  and  compress  in  a  tablet 
machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 

Alternate  Formula. 

Theobromine  sodio-salicylate 1.50  Gm. 

Saccharin 0.06  Gm. 

Liquid  petrolatum 0.50  Cc. 

Spirit  of  peppermint 0.60  Cc. 

Fat  starch 5. 00  Gm. 

Sugar,  powdered 23.00  Gm. 

Mix  the  theobromine  sodio-salicylate  and  the  saccharin 
with  the  spirit  of  peppermint  and  permit  the  alcohol  to  evap- 
orate. Add  the  liquid  petrolatum  and  triturate.  Finally 
incorporate  the  sugar  by  thorough  trituration  and  the 
fat  starch  by  gentle  trituration;  and  compress  in  a  tablet 
machine,  using  3/8-inch  die  and  punches,  to  make  one 
hundred  0.30  Gm.  tablets. 


FORMULARY.  71 

58.  TABELLAE  THYROIDEAE  DULCES. 
Swe^t  Tablets  of  Thyroid. 

0.06  Gm.  (gr.  1). 

Desiccated  thyroid  gland 6.00  Gm. 

Cinnamon  cacao  sugar 19.00  Gm. 

Mix  by  thorough  trituration  in  a  mortar  and  compress  in 
a  tablet  machine,  using  3/8-inch  die  and  punches,  to  make 
one  hundred  0.25  Gm.  tablets. 

Alternate  Formula. 

Desiccated  thyroid  gland 6.00  Gm. 

Spirit  of  cinnamon 0.15  Cc. 

Cacao  powder 2.00  Gm. 

Sugar,  powdered 17.00  Gm. 

Directions,  same  as  above. 


CHAPTER  VIII. 
FORMULAE  FOR   STOCK  PREPARATIONS. 

(Referred  to  in  Chapter  VII.) 

1.  FAT   STARCH. 
Alcoholic  solution  of  saccharin,  3%,*.  15.00  Cc. 

Liquid  petrolatum, 25.00  Cc. 

Starch 75.00  Gm. 

Mix  the  starch  with  the  solution  of  saccharin,  and  permit 
the  alcohol  to  evaporate  completely.  Then  incorporate  the 
liquid  petrolatum. 

2.  CINNAMON  CACAO  SUGAR. 

Spirit  of  cinnamon,  10% 0.50  Cc. 

Cacao  powder 10.00  Gm. 

Dextrose  *  * 10.00  Gm. 

Sugar,  powdered 80.00  Gm. 

Mix  thoroughly  by  trituration  in  a  mortar;  and  preserve 
in  a  well-stoppered  bottle. 

3.   GREEN  FAT  SUGAR. 

Spirit  of  gaultheria,  10% 4.00  Cc. 

Solution  of  malachite  green,  1:1000.  .   4.00  Cc. 

Fat  starch 20. 00  Gm. 

Sugar,  powdered 80.00  Gm. 

Mix  the  powdered  sugar  with  the  solution  of  malachite 
green;  permit  to  dry.  Add  the  fat  starch  and  the  spirit  of 
gaultheria,  and  preserve  in  a  well-stoppered  bottle.  Keep 
in  a  dark  place. 

4.   PINK  FAT  SUGAR. 

Solution  of  carmine,  N.  F 0.50  Cc. 

Spirit  of  rose,  1% 2.00  Cc. 

Fat  starch 20.00  Gm. 

Sugar,  powdered 80.00  Gm. 

Add  the  solution  of  carmine  to  the  sugar  and  triturate 
until  thoroughly  mixed.  Then  add  the  fat  starch  and  the 
spirit  of  rose,  and  preserve  in  a  well-stoppered  bottle  in  a 
dark  place. 

*  Not  absolutely  necessary. 

**  Equivalent  amount  of  sugar  might  be  used   though  powder  may  not 
work  quite  as  well  in  machine. 


FORMULAE  FOR  STOCK  PREPARATIONS.  73 

5.   RED  FAT  SUGAR. 

Solution  of  carmine,  N.  F 6.00  Cc. 

Spirit  of  cinnamon,  10% 1.00  Cc. 

Fat  starch 20.00  Gm. 

Sugar,  powdered 80.00  Gm. 

Mix  the  carmine  solution  with  the  sugar  and  permit  the 
powder  to  dry.  Then  add  the  spirit  of  cinnamon.  Owing 
to  the  fact  that  the  red  fat  sugar  is  used  with  poisonous 
substances  requiring  very  thorough  trituration  which  is 
liable  to  lessen  the  efficiency  of  the  fat  starch,  it  is  well  to 
add  the  latter  after  the  medicament  has  been  incorporated 
with  the  red  cinnamon  sugar.  Preserve  in  a  well-stoppered 
bottle    in    a    dark  place. 

6.  VANILLA  CACAO  SUGAR. 

Tincture  of  vanilla 5.00  Cc. 

Cacao  powder 10.00  Gm. 

Dextrose* 10.00  Gm. 

Sugar,  powdered 80.00  Gm. 

Mix  thoroughly  by  trituration  in  a  mortar,  and  preserve 
in  a  well-stoppered  bottle. 

7.  WHITE  FAT  SUGAR. 

Spirit  of  peppermint 2.00  Cc. 

Fat  starch 20.00  Gm. 

Sugar,  powdered 80.00  Gm. 

To  the  powdered  sugar  add  the  fat  starch  and  the  spirit 
of  peppermint.  Mix  and  preserve  in  a  well-stoppered  bottle 
in  a  dark  place. 

8.  YELLOW  FAT  SUGAR. 

Spirit  of  lemon,  10% 5.00  Cc. 

Tincture  of  curcuma 10.00  Cc. 

Fat  starch 20.00  Gm. 

Sugar,  powdered 80.00  Gm. 

Mix  the  powdered  sugar  with  the  tincture  of  curcunia  and 
permit  the  alcohol  to  evaporate;  then  add  the^  spirit  of 
lemon  and  the  fat  starch.  Mix  well  and  preserve  in  a  well- 
stoppered  bottle  in  a  dark  place. 

*  Equivalent  amount  of  sugar  might  be  used,  though  powder  may  not 
work  as  well  in  machine. 


REFERENCES. 


^Fantus,  B. — Candy  Medication,  Journal  of  the  American 
Medical  Association,  September  14,  1912,  Vol.  LIX, 
p.  842. 

^Sawyer,  Sir  James — The  Lancet,  August  12,   1911,  p.  435 

^Fantus,  B. — Tabellae  Dulces,  Journal  of  the  American  Pharr 
maceutical  Association,  May,  1914,  Vol.  III. 

^Fuller,  Robert  M. — Dose  Dispensing  Simplified,  New  Reme- 
dies, March,  1878,  p.  69. 

^Schleimer,A. — The  National  Druggist,  February,  1909,  p.  54. 

^Fantus,  B. — Candy  Medication  Formulary,  Journal  of  the 
National  Association  of  Retail  Druggists,  May  22  and 
29,  and  June  12  and  13,  1913,  Vol.  XVI,  pp.  407,  471, 
599,  663. 

"^Fantus,  B. — The  Making  of  Tablets  by  the  Retail  Druggist, 
Journal  of  the  American  Pharmaceutical  Association, 
January,  1914,  Vol.  Ill,  No.  1,  p.  72. 

^Wood,  Joseph  R. — Tablet  Manufacture,  J.  B.  Lippincott  Co., 
Philadelphia,  Pa. 

^Lloyd,  John  Uri — Lloyd's  Reagent,  Preliminary  Announce- 
ment, Journal  of  the  American  Pharmaceutical  Associa- 
tion, May,  1914,  Vol.  Ill,  No.  5,  p.  625. 


INDEX 

A 
Absorbents,  17 

Alcresta  Strychnine,  33 
Anhydrotic,  19 
Antacids,  17 
Anthelmintic,  18 
Antidiarrheals,  17 
Antiemetics,  17 
Antipyretics,  20 
Antiseptic,  Urinary,    19 
Antiseptics,  Intestinal,  18 
Antispasmodics,  18 
Antitussic,  18 
Aromatic  Calomel,  11 

C 

Cacao  butter  process,  24 

"Capping",  30 

Cathartics,  18 

Chocolate  creams,  medicated,  12 

Choice  of  color,  34 

Choice  of  flavor,  31 

Cinnamon  Cacao  Sugar,  72 

Circulatory  depressant,  19 

Circulatory  stimulants,  19 

Color,  choice  of,  34 

Confection,  11 

Construction  of  Formulae,  31 

Cough  Remedies,  18 

Cremulae,  12 

D 

Depressants,  19 

Depressant,  Circulatory,  19 

Diaphoretics,  19 

Difficulties  in  Tablet  Making,  29,  36 

Diuretics,  19 


INDEX  77 

£ 


Emetics,  17 

Eureka  Tablet  Machine,  27 

Expectorants,  18 

F 

Fat  covering,  25,  32 

Fat  starch,  72 

Fat  sugars,  72,  73 

Fat  sugar  process,  24 

Flavor,  choice  of,  31 

Fondant,  12 

Formulae,  construction  of,  31 

Formulae  for  stock  preparations,  72 

Formulae  for  sweet  tablets,  35 

Formulary,  36-71 

Fuller's  earth,  33 

G 

Green  fat  sugar,  72 

H 

Hematinics,  20 

Historical  Introduction,  11 

I 

Indications  for  sweet  tablets,  16 
Intestinal  antiseptics,  18 

L 

Lloyd's  Reagent,  33 
Lozenges,  11 

M 
Machine,  Tablet,  27 
Making  of  sweet  tablets,  23 
Malaria,  specifics  in,  20 
Myxedema,  specific  in,  20 

O 

Objections  to  sweet  tablets,  21 


78  CANDY  MEDICATION. 


Paraffin  process,  24 
Phenolax,  11 
Pink  fat  sugar,  72 
Purgen,  11 


R 


References,  75 

Red  fat  sugar,  73 

Rheumatic  fever,  specifics  in,  20 

S 

Saccharinization,  32 
Specifics,  20 
"Sticking,"  29 
Stimulants,  20 
Stimulants,  circulatory,  19 
Stock  preparations,  72 
Subduing  of  tastes,  31 
Sweet  Tablets: 

Acetphenetidin,  36 

Acetylamidosalol,  37 

Acetylsalicylic  Acid,  37 

Aconitine,  37 

Adalin,  38 

Alcresta  Strychnine,  66 

Anaesthesine,  39 

Antimony  and  Potassium  Tartrate,  39 

Antipyrene,  40 

Apomorphine,  40 

Aristochin,  41 

Arsenic  Trioxide,  42 

Aspirin,  37 

Atropine,  42 

Bismuth  Subcarbonate,  43 

Bismuth  Subnitrate,  43 

Caffeine,  44 

Calomel,  54 

Cerium  Oxalate,  45 


INDEX  f9 


Sweet  Tablets — (cont'd) : 

Chalk,  46 

Charcoal,  45 

Cocaine,  46 

Digitalis,  47 

Diuretin,  70 

Dover's  Powder,  57 

Elaterin,  48 

Emetine,  48 

Ferrous  Carbonate,  50 

Heroine,  52 

Hexamethylenamine,  53 

Hyoscine,  56 

Ipecac  and  Opium,  57 

Iron  and  Arsenic,  50 

Iron,  Quinine  and  Strychnine,  51 

Jalap,  61 

Lactic  Acid  Ferment,  49 

Magnesia,  58 

Magnesium  Salicylate,  58 

Mercuric  Iodide,  Red,  56 

Mercurous  Chloride,  Mild,  54 

Mercurous  Iodide,  Yellow,  55 

Mercury  with  Chalk,  54 

Morphine,  59 

Nitroglycerine,  52 

Phenacetine,  36 

Phenolphthalein,  59 

Pilocarpine,  60 

Podophyllum,  61 

Reduced  Iron,  51 

Resin  Jalap,  61 

Resin  Podophyllum,  61 

Sabromin,  62 

Sajodin,  62 

Salophen,  37 

Saloquinine,  63 


80  CANDY  MEDICATION. 

Sweet  Tablets  (cont'd): 

Santonin,  64 

Senna,  64 

Sodium  Bicarbonate,  65 

Strophanthin,  65 

Strychnine,  66 

Sulphonal,  67 

Sulphonmethane,  67 

Sulphur,  68 

Tannalbin,  68 

Tartar  Emetic,  39 

Terpin  Hydrate,  68 

Terpin  Hydrate  with  Heroine,  69 

Theobromine  Sodio-salicylate,  70 

Thyroid,  71 

Urotropin,  53 
Syphilis,  specifics  in,  20 
Tabellae  Dulces,  14 

Acetphenetidini,  36 

Acetylamidosaloli,  37 

Acidi  Acetylsalicylici,  37 

Aconitini,  37 

Adalini,  38 

Anaesthesini,  39 

Antimonii  et  Potassii  Tartratis,  39 

Antipyrinae,  40 

Apomorphinae,  40 

Aristochinae,  41 

Arseni  Trioxidi,  42 

Atropinae,  42 

Bismuthi  Subcarbonatis,  43 

Bismuthi  Subnitratis,  43 

Caffeinae,  44 

Carbonis  Ligni,  45 

Cerii  Oxalatis,  45 

Cocainae,  46 

Cretae,  46 


INDEX  81 


Tabellae  Dulces  (cont'd) : 

Digitalis,  47 

Elaterini,  48  ♦' 

Emetinae,  48 

Fermenti  Acidi  Lactici,  49 

Ferri  Carbonatis,  50 

Ferri  et  Arseni,  50 

Ferri  Reducti,  51 

Ferri,  Quininae  et  Strychninae,  51 

Glycerylis  Nitratis,  52 

Heroinae,  52 

Hexamethylenaminae,  53 

Hydrargyri  Chloridis  Mitis,  54 

Hydrargyri  cum  Creta,  54 

Hydrargyri  lodidi  Flavi,  55 

Hydrargyri  lodidi  Rubri,  56 

Hyoscinae,  56 

Ipecacuanhae  et  Opii,  57 

Magnesii  Oxidi,  58 

Magnesii  Salicylatis,  58 

Morphinae,  59 

Phenolphthaleini,  59 

Pilocarpinae,  60 

Resinae  Jalapae,  61 

Resinae  Podophylli,  61 

Sabromini,  62 

Sajodini,  62 

Saloquininae,  63 

Santonini,  64 

Sennae,  64 

Sodii,  Bicarbonatis,  65 

Strophanthini,  65 

Strychninae,  66 

Sulphonmethani,  67 

Sulphuris,  68 

Tannalbini,  68 

Terpini  Hydratis,  68 


82  CANDY  MEDICATION. 

Tabellae  Dulces  (cont'd) : 

Terpini  Hydratis  cum  Heroina,  69 
Theobrominae  Sodio-salicylatis,  70 
Thyroideae,  71 

Tablet  machine,  27 

Tablet  machine,  F.  T.  Stokes  Co.,  27 

Tablet  machine,  Whitall-Tatum  Co.,  27 

Tamar  Indien,  12 

Tastes,  subduing  of,  31 

Tonics,  20 


Urinary  antiseptics,  19 
Uses  of  sweet  tablets,  16 

Vanilla  Cacao  sugar,  23 
Vaso-dilator,  19 

White  fat  sugar,  73 

Yellow  fat  sugar,  73 


U 


W 


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